Radiotherapy

• Our staff
   

  Radiotherapy

  Director

  Barbara Alicja Jereczek

  • Brachytherapy Unit

    Director ad interim Barbara Alicja Jereczek

  Staff Radiotherapy

  • • High specialized physician Daniela Alterio
    • High specialized physician Roberta Lazzari
    • High specialized physician Maria Cristina Leonardi
    • Physician Luca Bergamaschi
    • Physician Giulia Corrao
    • Physician Samantha Dicuonzo
    • Physician Stefano Durante
  • • Physician Annamaria Ferrari
    • Physician Marianna Alessandra Gerardi
    • Physician Giulia Marvaso
    • Physician Federico Mastroleo
    • Physician Giovanni Carlo Mazzola
    • Physician Anna Morra
    • Physician Gaia Piperno
  • • Physician Damaris Patricia Rojas
    • Physician Andrea Vavassori
    • Physician Stefania Volpe
    • Physician Maria Alessia Zerella
    • Physician Dario Zerini
• offered treatments

  • Cyberknife System - This is a miniature linac dedicated to robot-assisted radiosurgery i.e. delivery of a single high dose of radiation, stereotactically directed to the target. Robotic arm enables the system to deliver radiation from many different directions, verifying instantaneously the target position. This non-invasive, frameless, high precision (submillimetric accuracy) approach allows delivery of the ablative dose to any part of the human body. In IEO, CyberKnife is employed for radiosurgery of primary and metastatic cranial and spine tumors, selected tumors of lung, pancreas, liver and other abdomino-pelvic malignancies.

  • Vero System - This is the world's first real-time dynamic tracking irradiation system that is capable of accurately tracking the position of tumors that move inside patient's body due to respiration, for example, and thereby enables highly precise, uninterrupted X-ray irradiation to the targeted tumor. In a short time irradiation can be precisely delivered to several moving targets. In IEO, Vero is employed in the management of prostate cancer, and small thoracic or abdomino-pelvic primary or metastatic tumors.

  • TomoTherapy - This is a novel system that combines CT imaging with a radiation treatment delivery system that administers the dose slice-by-slice. With this unique design, the intensity of the radiation beam delivered conforms to the patient’s tumor and helps avoid critical structures as the machine rotates 360 degrees around the patient. Large and irregularly shaped areas may be adequately treated. In IEO, TomoTherapy is employed for the postoperative breast radiotherapy as a single treatment or combined with introperative radiation boost (given during breast surgery).

  • Trilogy™ System - This advanced radiotherapy versatile technology enables several irradiation modalities, including RapidArc approach (Volumetric Modulated Arc Therapy). By using real-time diagnostic data, the sculpted radiation beam pinpoints the tumor and protects the surrounding healthy tissue, while minimizing the patient's time on the treatment table. High precision radiation is delivered two to eight times faster than any other system making the experience more comfortable for the patient. In IEO, Trilogy is employed for the head and neck cancer tumors (enabling parotid sparing approach) and for large pelvic volumes (gynecological, urological or intestinal malignancies when pelvic lymph nodes irradiation is necessary).

  

   

• CLINICAL TRIALS IN EVIDENCE
  • • Multicenter phase IIb/III randomized trial in patients with breast cancer, on the postoperative external beam radiotherapy comparing conventional fractionation with 2 accelerated hypofractionation with concomitant boost schemes. MIRA-SOLE trial. IEO S639/311.

  • Randomized phase II clinical study in patients undergoing intraoperative boost to the tumor bed witrh electrons (ELIOT) followed by postoperative accelerated hypofractionated external beam radiotherapy after conservative surgery for early-stage breast cancer. IEO S676/61.

  • Prospective research grant of the Italian Association of Cancer Research (Associazione Italiana per la Ricerca sul Cancro, AIRC) IG-13218: Short-term high precision radiotherapy for early prostate cancer with concomitant boost on the dominant lesion.

  • Prospective research grant of the Italian Association of Cancer Research (Associazione Italiana per la Ricerca sul Cancro, AIRC) IG-N14300: Carbon ions boost followed by pelvic photon radiotherapy for high risk prostate cancer.
  • Prospective current research projects of the Italian Ministry of Health on breast, prostate and head and neck malignancies.

• publications

  Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, Luini A, Veronesi P, Galimberti V, zurrida S, Leonardi MC, Lazzari R, Cattani F, Gentilini O, Intra M, Caldarella P, Ballardini B. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a  randomised controlled equivalence trial. www.ncbi.nlm. nih.gov/pubmed/24225155 Lancet Oncol. 2013 Dec;14(13):1269-77.

   

  Jereczek-Fossa BA, Santoro L, zerini D, Fodor C, Vischioni B, Dispinzieri M, Bossi-zanetti I, Gherardi F, Bonora M, Caputo M, Vavassori A, Cambria R, Garibaldi C, Cattani F, Matei DV, Musi G, De Cobelli O, Orecchia R. Image guided hypofractionated radiotherapy and quality of life for localized prostate cancer: prospective longitudinal study in 337 patients. www.ncbi.nlm.nih.gov/pubmed/23313200 J Urol. 2013 Jun;189(6):2099-103.

   

  Leonardi MC, Maisonneuve P, Mastropasqua MG, Morra A, Lazzari R, Dell’Acqua V, Ferrari A, Rotmensz N, Sangalli C, Luini A, Veronesi U, Orecchia R. Accelerated partial Breast irradiation with intraoperative electrons: using GEC-ESTRO recommendations as guidance for patient selection. www.ncbi.nlm.nih.gov/pubmed/23218711 Radiother Oncol. 2013 Jan;106(1):21-7.

   

  Leonardi MC, Maisonneuve P, Mastropasqua MG, Morra A, Lazzari R, Rotmensz N, Sangalli C, Luini A, Veronesi U, Orecchia R. How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology. www.ncbi.nlm.nih.gov/pubmed/22245196 Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):806-13.

   

  Jereczek-Fossa BA, Beltramo G, Fariselli L, Fodor C, Santoro L, Vavassori A, zerini D, Gherardi F, Ascione C, Bossi-zanetti I, Mauro R, Bregantin A, Bianchi LC, De Cobelli O, Orecchia R. Robotic image-guided stereotactic radiotherapy, for isolated recurrent primary, lymph node or metastatic prostate cancer. www.ncbi.nlm.nih.gov/pubmed/21277113 Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):889-97.