Laboratory Medicine

Director

Rita Passerini

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Clinical Trials

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The Division oversees many research projects. The main ones are:

Evaluation of the prognostic and predictive value of the tumoral cells in breast cancer patients at different stages

The role of different HPV high risk genotypes in the developing of pre-malignant lesions and in the follow up of patients that underwent Cervical conization

Study of different HPV genotypes and their variations in time among HPV vaccinated teenagers in trying to prevent cervical canc

Early identification of patients at high risk to develop post chemotherapy cardio toxicity through the dosage of the circulating biomarkers.

Evaluation of the newly discovered tumoral markers in circulation both for diagnosis and triage in patients with suspicious lesions.

Our Activities

The Division of Laboratory Medicine encompasses the fields of hematology, biochemistry, coagulation, tumor markers, infectious disease serology, drug monitoring and microbiology; it carries out examinations both for hospitalized patients and out patients.

The Blood Drawing Center is located in IEO Building 2, ground floor.
Its services are open from Monday to Friday from 7.30am to 12 am for all patients starting from age 11. All patients must have a NHS medical receipt (if they want to be covered by the National Health System) or with a written indication from his doctor or specialist.

In collaboration with the Unit of Preventive Gynecology the Division has activated a new diagnostic service for cervical tumors at the use of all doctors for the prevention and monitoring of such tumors.

All our examinations are performed by our highly qualified experts and always up to date.
The results of the exams are ready right away for our specialists, who can access them thanks to an internal software.
The laboratory has obtained and keeps on having confirmed the ISO 9001/2008 certification.

Our staff

Laboratory Medicine
Director
Rita Passerini
graduated residents

Our graduated residents (biologists) are an integral part of the staff:

Rita Passerini (Senior Deputy-Director)

Laura Zorzino (Senior Deputy-Director)

Michela Salvatici (Senior Assistant

Paola Lentati (Assistant)

Cristina Cassatella (Assistant)

Fabio Bottari (Assistant)

Cristian Mauro (Fellow)

Donatella Gritti (Assistant- Transfusional Service)

Annalisa Cattaneo (Assistant - Transfusional Service)

Giovanna Randine (Assistant- Transfusional Service).
Clinical Trials
- Prospective characterization of circulating tumor cells in patients with hormone receptor positive metastatic breast cancer. The aim of the study is to evaluate the presence of circulating tumor cells, isolated from whole blood, in women with metastatic breast cancer treated with hormonal therapy. The cells will be characterized and a special focus will be on the detection of specific markers which may be used to guide a personalized therapy.
- Evaluation of the prognostic role of Circulating Tumor Cells (CTCs) in patients with HER2 positive or triple negative tumor, during neoadjuvant chemotherapy. The aim of the study is the evaluation of the presence of circulating tumor cells in women undergoing or pre-operative chemotherapy or directly surgery. Two methods will be used: one which allows the enumeration of the cells, and a second method which allows the evaluation of the presence of cells presenting EMT or stemness characteristics.
- Use of new molecular tests in the diagnosis and follow-up of women with cervical lesions. The study will compare different methods for the detection of HPV in cervical
  samples from women with a lesion undergoing conservative surgery with the aim of identifying a more specific approach to detect those women who will present a relapse.
- Impact of prophylactic vaccination with Gardasil in a eighteen-year old women. Women will be vaccinated with a prophylactic vaccine against the genotype 16, 18, 6 and 11 of HPV. The women will be followed for 5 years with annual visit, HPV testing and in case of positivity genotyping. Aim of the study is to evaluate the change in HPV infection, with genotypes related or non-related to the vaccine, the incidence of HPV test positivity and of high grade lesions during the follow-up.

Where research becomes treatment in real time

Laboratory Medicine

Rita Passerini

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Our Activities

Laboratory Medicine

Rita Passerini