Activities
Our lab pursues the following lines of research:
• Modeling disease through cell reprogramming. We harness the unprecedented potential of cell reprogramming to develop physiopathologically meaningful models of both neurodevelopmental disorders and cancer.
• Epigenetic regulation of neural fate. We study the role of two major pathways of chromatin regulation, methylation of histone H3 on lysine tails 4 and 27, on the acquisition of neuronal fate, with a special focus on corticogenesis.
• Aberrant genome programming in brain cancer. Consistent with the role of Polycomb-mediated H3K27 methylation in lineage choices, this line of research investigates the oncogenic counterpart of the acquisition of neural fate, focusing on malignant gliomas, combining advanced murine models with the analysis of human tumors.
• Epigenetics of cell fate reprogramming. Finally, consistent with the role of the Trithorax and Polycomb families in cell fate transitions, we study their contribution to cell fate reassignment, both for induced pluripotency and direct transdifferentiation.