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Viral control of cellular pathways and biology of tumorigenesis

Director

Susanna Chiocca

HIGHLIGHTS

 

We are part of the LIBRA  Consortium (http://www.eu-libra.eu), a Coordination and Support Action project funded by the European Commission’s framework programme H2020 to boost gender equality in research.

Activities

The overall focus of my research lab is to determine the mechanisms by which oncogenic viruses and other tumor microenvironmental stresses contribute to neoplasia by post-translational modification of proteins. In particular, we have been studying the virus-/stress-induced SUMOylation and phosphorylation of Histone Deacetylases (HDACs) to show how this changes the neoplastic program, primarily through altering the cancer epigenome.

  • Research projects

    Our research laboratory is currently pursuing two major projects:

     

    A.

    The biology of HDAC1 (and HDAC2) and how its post-translational modifications cross-talk and control its activity, also in light of its potential significance as a target for cancer therapy.

     

    B.

    The regulation and exploitation of the SUMO (Small Ubiquitin-like-Modifier)  pathway by oncoviral proteins.

     

     

  • Educational Activities

    Since 2005 faculty member of SEMM.

     

    Co-Organizer of the Fundamental Principles in Molecular Oncology Course for the PhD programme

     

     

  • Publications

    • BC-box protein domain-related mechanism for VHL protein degradation. Pozzebon ME, Varadaraj A, Mattoscio D, Jaffray EG, Miccolo C, Galimberti V, Tommasino M, Hay RT, Chiocca S. Proc Natl Acad Sci U S A. 2013 Oct 21. [Epub ahead of print] PMID: 24145437 [PubMed - as supplied by publisher]
    • Molecular and biological analysis of histone deacetylase inhibitors with diverse specificities. Johnstone RW, Newbold A, Matthews GM, Bots M, Cluse LA, Clarke CJ, Banks KM, Cullinane C, Bolden JE, Christiansen AJ, Dickins RA, Miccolo C, Chiocca S, Kral AM, Ozerova ND, Miller TA, Methot JL, Richon VM, Secrist JP, Minucci S. Mol Cancer Ther. 2013 Oct 3. [Epub ahead of print]
    • A role for paralog-specific sumoylation in histone deacetylase 1 stability. Citro S, Jaffray E, Hay RT, Seiser C, Chiocca S. J Mol Cell Biol. 2013 Sep 25. [Epub ahead of print].
    • Viral manipulation of cellular protein conjugation pathways: the SUMO lesson Mattoscio D, Segre’ CV, Chiocca S. World Journal of Virology. 2013 May 12; 2(2)
    • A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance. Santoro F, Botrugno OA, Dal Zuffo R, Pallavicini I, Matthews GM, Cluse L, Barozzi I, Senese S, Fornasari L, Moretti S, Altucci L, Pelicci PG, Chiocca S, Johnstone RW, Minucci S. Blood. 2013 Feb 25. [Epub ahead of print]

     

    All publications

A SMALL GESTURE IS A GREAT HELP FOR US

PARTNERSHIP

Università degli Studi di Milano Ecancer Medical Science IFOM-IEO Campus

CREDITS

Ministero della Salute Joint Commission International Breastcertification bollinirosa

© 2013 Istituto Europeo di Oncologia - via Ripamonti 435 Milano - P.I. 08691440153

IRCCS - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

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