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Myriam Alcalay

DIRECTOR

Functional Genomics

  • Research activities

    High-throughput technologies have become essential for the discovery and analysis of genetic networks underlying cancer. Recent technological advancements, in particular next-generation sequencing, allow for a more comprehensive analysis of complex molecular interactions that accompany neoplastic transformation and tumor progression. The concerted use of these approaches to discover and characterize genetic and epigenetic events that are relevant to oncogenesis is one of the current challenges in the field of functional genomics applied to cancer research.

  • Publications

    • A. M. Gruszka and M. Alcalay (2013). PML/RARα Fusion Gene and Response to Retinoic Acid and Arsenic Trioxide Treatment. Handbook of Therapeutic Biomarkers in Cancer. Edited by Sherry X. Yang and Janet Dancey. Pan Stanford Publishing, ISBN: 9789814364652.
    • A. M. Gruszka and M. Alcalay (2012). Clinical and Biological Relevance of Gene Expression Profiling in Acute Myeloid Leukemia, Myeloid Leukemia - Clinical Diagnosis and Treatment, Steffen Koschmieder and Utz Krug (Ed.), ISBN: 978-953-307-886-1, InTech, Available from:http://www.intechopen.com/articles/show/title/clinical-and-biological-relevance-of-gene-expression-profiling-in-acute-myeloid-leukemia.
    • C. Giampietro, A. Taddei, M. Corada, G.M. Sarra-Ferraris, M. Alcalay, U. Cavallaro, F. Orsenigo, M.G. Lampugnani, E. Dejana: Overlapping and divergent signalling pathways of N- and VE-cadherin in endothelial cells. Blood, 2012, Mar 1;119(9):2159-70.
    • E. Pelosi, G. Castelli, I. Martin-Padura, V. Bordoni, S. Santoro, A. Conigliaro, A.M. Cerio, M De Santis Puzzonia, P. Marighetti, M. Biffoni, T. Alonzi, L. Amicone, M. Alcalay, F. Bertolini, U. Testa, M. Tripodi.: Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium. PLoS One, 2012;7(12):e51109. doi: 10.1371/journal.pone.0051109. Epub 2012 Dec 4.
    • E. Colombo, M. Alcalay and P.G. Pelicci: Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases. Oncogene, 2011, 2011 Jun 9;30(23):2595-609.

UN PICCOLO GESTO E' PER NOI UN GRANDE AIUTO

PARTNERSHIP

Università degli Studi di Milano Ecancer Medical Science IFOM-IEO Campus

CREDITS

Ministero della Salute Joint Commission International Breastcertification bollinirosa

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