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Rosella Visintin

DIRECTOR

Chromosome Segregation Unit

  • Research activities

    My laboratory is interested in understanding the molecular mechanisms that control cell division, the process by which a cell generates two genetically identical daughter cells. For this to occur, cells need to replicate their chromosomes and faithfully distribute each copy into the daughter cells. To ensure that each cell receives only one copy of each chromosome, cell cycle events need to be coordinated in time and space. If these mechanisms fail then genomic integrity is lost, which can lead to cell death or the acquisition of proliferation abnormalities. In particular, we focus on mitosis, the phase of the cell cycle during which replicated genomes are separated and packaged into daughter nuclei. We study chromosome segregation to better understand how errors made during this process contribute to the transformation of a healthy cell into a cancerous one.

  • Publications

    • Visintin R. (2011). Cdc14B: when a good kid turns bad. Cell Cycle 10:2416-7.
    • Manzoni, R., Montani F., Visintin C., Caudron F., Ciliberto A., and Visintin R. (2010). Oscillations in Cdc14 release and sequestration reveal a circuit underlying mitotic exit. JCB, 190: 209-222.
    • De Wulf P., Montani F. and Visintin R. (2009). Phosphatases take the cell cycle stage. Current Opinion in Cell Biology, 21:806-15
    • De Wulf P. and Visintin R. (2008). Cdc14B and APC/C takle DNA damage. Cell, 134: 210-2
    • Visintin C., Tomson B.N., Rahal R., Paulson J., Cohen M., Taunton J., Amon A. and Visintin R.. (2008). Apc/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes Dev, 22: 79-90


    All publications

UN PICCOLO GESTO E' PER NOI UN GRANDE AIUTO

PARTNERSHIP

Università degli Studi di Milano Ecancer Medical Science IFOM-IEO Campus

CREDITS

Ministero della Salute Joint Commission International Breastcertification bollinirosa

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