Radiomics development and application in the head and neck region represent an emerging field. Scientific studies are limited and mostly focused on nasopharynx and oropharynx cancers. In this context, the purpose of radiomics is to improve predictive and prognostic models, for enabling personalized treatments. During the diagnostic work up, imaging plays a fundamental role: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) represent the gold standard for loco-regional staging of Head and Neck cancers, to study the patients’ disease and to plan the correct treatment approach. A study on the application of radiomic analysis in preoperative MRI in Oral Tongue Squamous Cell Carcinoma (OTSCC) is currently ongoing at IEO. This study aims to identify biomarkers useful for prognostic purposes applying radiomics to preoperative MRI of patients with OTSCC. We evaluate the possible association between the features extracted from radiomic analysis and oncological outcomes to investigate parameters that can be used in estimating preoperatively the prognosis of these patients. Our preliminary results indicate that for all models the integration of radiomics features to standard clinical models implements the level of accuracy. According to our data, integration of radiomics to standard clinical models increase the accuracy in estimating patients’ prognosis providing accurate information before surgery.