Bernardo Bonanni

Speciali Expert of the Personalized Clinical Prevention and management of subjects at high risk.

Director

Cancer Prevention and Genetics

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• CLINICAL ACTIVITIES

  Dr Bonanni has dealt with personalized clinical prevention for years, with the objective of managing subjects with personal and/or strong family history of tumors or precancerous lesions and implementing targeted strategies for risk reduction.

  In cancer prevention, the precise selection of the subjects is important, based on multi-factorial oncologic risk assessment taking into account: age, lifestyles, late pregnancies, endocrine / metabolic factors, and familiarity/genetics, etc.

   

  Through accurate, clinical and instrumental surveys and the use of biostatistics models of evaluation, it is today possible to calculate the level of risk of one subject for some types of cancer, that can be managed with various combinations of regular check-ups and preventative measures (consulting for Drug Prevention - trial or off-trial - and lifestyle change; consulting on onco-genetics - counseling and genetic testing, intensive surveillance, prophylactic surgery, etc.).

  Dr Bonanni has taken on a lot of the management of high-risk candidates for genetic testing and counseling, follow-up and measures of cancer prevention. He has been the coordinator of the multidisciplinary High Risk Clinic at IEO since 2005, that provides:

  • Genetic Counseling and Genetic Testing
  • Multidisciplinary (panel of experts) Consults
  • Programs of intensive clinical and instrumental Surveillance
  • Studies on drug prevention and modification of lifestyles
  • Personalized programs of Prophylactic Surgery.
• RESEARCH ACTIVITIES
  Dr Bonanni coordinates (as PI or co-PI) various networks of clinical research for conducting national and international multicenter studies of phase II and III, participating in the conception, development, interpretation, discussion and publication, enrollment of patients as well as in the care of the clinical aspects of the studies, including the evaluation of the toxicity and the determination of the minimum active dose of the medications.

   

  The collaboration for several oncology and genetics research projects with prestigious international research institutions is well established, including: Division of Cancer Prevention of the US National Cancer Institute; M.D. Anderson's Cancer Center; Consortium for Chemoprevention Trials at NCI; Cancer Research UK; International Breast Cancer Study Group (IBCSG); Department of Endocrinology, University of Bergen; International Agency for Cancer Research on Cancer (IARC) in Lyon; Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA); Consortium for the Study of the MMR alleles and their modifiers (CONSAMM); Breast Cancer Association Consortium (BCAC).

   

• EDUCATIONAL ACTIVITIES
  Dr Bonanni has participated as a speaker, chairman, member/advisor of Scientific Committee in numerous national and international conferences since 1994.

  He has been a Professor of the Masters in Breast Care, Drug-Oncology, and Prevention and Clinical Genetics at the University of Milan, the University of Insubria, the University of Siena, and at the Italian School of Breast Care since 1995.

   

  He has been the coordinator of the Clinical Genetics Task Force at the European Institute of Oncology since 1995, involving a network of numerous Italian centers of research and care regarding:

  • Genetic counseling and genetic testing
  • Revision of guidelines and hereditary syndromes
  • Discussion of clinical cases, and tailored preventive strategies
  • Training initiatives

  He has been a Contract Professor at the University of Tor Vergata - Rome since 2009.

  He is affiliated to the following Societies:

  • From 2013: Deputy Director of the Executive Committee of the Italian Association for the Study of Familial and Hereditary Gastrointestinal Cancers (AIFEG) of which he has been a member since 2010.
  • Since 2010: Member of the Italian Society of Human Genetics (SIGU)
  • Since 2009: Member of the American Society of Clinical Oncology (ASCO)
  • Since 2002: Member of the American Association for Cancer Research (AACR)
  • Since 1996: Member of the International Society for Cancer Chemoprevention (ISCaC)
  • Since 1992: Member of the European Society of Mastology (EuSoMa)
  • Since 1988: Member of the Italian Cancer Society (SIC)

  He is the author of over 120 publications in the most prestigious scientific journals

  • In December 2002 he won the "Bruno Martinetto" Prize for Chemoprevention
  • In November 2012 he won the LILT and Foundation Cassa di Risparmio of Asti Prize "For Genetic Research Against Cancers".