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Bladder Cancer

At the European Institute of Oncology, a specialised team is dedicated to the diagnosis and treatment of bladder cancer guaranteeing comprehensive patient management by integrating medical and nursing competencies and placing the patient at the centre of the therapeutic process with an active role at each step.

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IN SHORT

Bladder cancer is the fourth most common urological cancer in men and the second most frequent cancer affecting the urinary tract. Bladder cancer begins when cells in the urinary bladder start to grow uncontrollably. As more cancer cells develop, they can form a tumor and spread to other areas of the body. At the time of diagnosis, 70% of patients are experiencing non-muscle-invasive bladder cancer.

RISKS OF BLADDER CANCER

The causes of bladder cancer are unknown, but some potential risk factors that can promote its onset can be identified:

  • Smoking is the most important risk factor. The incidence of bladder cancer is directly related to the years of exposure, the number of cigarettes smoked and early age of starting smoking.
  • Chronic exposure to certain substances, particularly benzene derivatives and aromatic amines can develop bladder cancer.
  • Urinary schistosomiasis, a parasitic infection endemic in Africa, Asia, South America, associated with the development of squamous cell type bladder cancer.

 

  • A high proportion of upper urinary tract urothelial carcinomas (60%) are invasive at the time of diagnosis. The diagnosis of upper urinary tract urothelial carcinomas, especially in early stages, is difficult and in many cases fortuitous. Typical bladder cancer symptoms such as hematuria and flank pain are unspecific, and a lumbar mass is only detectable in 10–20% of all cases and reflects an advanced tumor stage

PREVENTION AND DIAGNOSIS

Bladder cancer symptoms.

Although bladder cancer can be completely asymptomatic at onset, one bladder cancer symptom is macro-haematuria (blood in urine). In cases of suspected bladder cancer, diagnostic procedures are based on ultrasound, radiology (urography and CAT), magnetic resonance and endoscopic methods, such as cystoscopy. The latter is the introduction of a fibre optic instrument into the bladder through the urinary tract and allows evaluation of the inside of the bladder and potentially taking samples of suspicious bladder cancer for analysis. A further diagnostic aid for bladder cancer is provided by searching for bladder cancer cells in the urine sample via urinary cytology. CAT, PET and bone scintigraphy are also useful for evaluating whether the bladder cancer has spread beyond the bladder, involving other organs. 

CARE AND CLINICAL TRIALS

Available surgical treatments of bladder cancer include transurethral resection (TURV), an often-decisive treatment for small non-infiltrating bladder cancer and cystectomy (removal of the organ). The therapeutic approach also includes the possibility of combined interventions employing chemotherapy and radiotherapy before, after or as an alternative to surgery with the intent of preserving the bladder in selected cases. 

Intravescical treatment with chemotherapeutic agents have high efficacy in metastatic non-infiltrating carcinoma. In advanced stage bladder cancer, the therapeutic approach is polychemotherapy with the aid of several drugs.

USEFUL LINKS

  • International Office

    The IEO International Office is fully dedicated to providing a tailored welcome and a comfortable hospital stay, by meeting all individual needs.

  • Request the IEO Second Opinion

    IEO Second Opinion is a service for who would like to confirm the diagnosis and treatments recommended by other physicians.

  • Contact Us

    An assistant from the IEO International Office will be glad to give you all information needed and personally assist you.

PARTNERSHIP

Università degli Studi di Milano Ecancer Medical Science IFOM-IEO Campus

CREDITS

Ministero della Salute Joint Commission International Breastcertification bollinirosa

© 2013 Istituto Europeo di Oncologia - via Ripamonti 435 Milano - P.I. 08691440153

IRCCS - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

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