CLOSE

Division of Epidemiology and Biostatistics

HIGHLIGHT


The Division has released the update of the Food Composition Database for Epidemiological Studies in Italy  BDA V1-2015! A new graphical interface, new food items and new components! Visit our website and discover all features! www.bda-ieo.it. Principal Investigator: Patrizia Gnagnarella (patrizia.gnagnarella@ieo.it)

  

 

The Tumour Registry was activated in March 2006 to provide global information on the activity of the hospital, to provide background information useful for the design of clinical studies, and to encourage clinicians and researchers to start new projects .By September 2015 data on more than 200,000 tumours were collected.

The Division of Epidemiology and Biostatistics is conducting epidemiological research activity on a wide range of topics, focusing on patients with cancer or on patients at increased risk of developing the disease. It has continuously attempted to develop international collaborative research programmes and as a result, the majority of the research activities involve co-operation with scientists from a range of disciplines, both intra-mural and extra-mural.

The Division is involved in the establishment and management of clinical research databases at the hospital and has responsibility upon data quality control.

The Division is running the IEO hospital-based tumour registry. The tumour registry was activated in 2006 and after 7 years of activity, by March 2013, data for 154,099 tumours were retrospectively coded and entered (out of 240,440 individuals presenting for the first time at the IEO over the period 2000-2008). The tumour registry has proven to be a valuable source of data for both epidemiological and clinical research and has been the basis for many research projects.

The Division also provides consultation in a wide range of areas including the statistical design of experiments and clinical trials, including sample size calculations and randomisation schemes, protocol development, database management, analysis of data and interpretation of results, preparation of interim reports and manuscripts. In addition, staff in the Division has developed a strong expertise in the field of statistical modelling and in the conduct of meta-analyses, providing important information to public-health policy makers and clinicians.

  • Research activities

    The Division is maintaining large institutional clinical databases which have been, already in the past, the basis for numerous studies, particularly the IEO Breast Cancer database. During 2013 a major research focus was made on the treatment, outcome and clinical aspects of breast cancer subtypes defined either by their molecular or morphological characteristics. Specific projects focussed on the outcome of very young women with breast cancer and of women who became pregnant after breast cancer. Other research interests in breast cancer during 2013 included the prognosis of breast cancer patients who underwent plastic or reconstructive surgery, investigating for example outcome after immediate breast reconstruction, nipple-sparing mastectomy or fat grafting.

     

    The Division contributed to the publication in 2013 of results from three major institutional randomised clinical trials: A randomised phase II pre-surgical trial of weekly low-dose tamoxifen versus raloxifene versus placebo in premenopausal women with oestrogen receptor positive breast cancer; a phase-III prevention trial of low-dose tamoxifen in postmenopausal hormone replacement therapy users: the HOT study; and a randomised controlled equivalence trial of Intraoperative radiotherapy versus external radiotherapy for early breast cancer:  the ELIOT trial.

     

    In summary, the statistical support activity of the Division led to the publication of 33 peer-review clinical research articles in various fields ranging from cancer screening, cancer chemoprevention, cancer treatment, cancer prognosis and cancer outcome. Most of this activity was related to cancer of the breast, lung, head and neck; to gynaecological, digestive or urogenital cancers; as well as haematological neoplasms.

     

    The Division is also largely involved in epidemiological studies and in collaborative research with other Italian or international institutions: In 2013, in collaboration with the US Cystic Fibrosis Foundation, it published results from a large cohort study of patients with cystic Fibrosis confirming an increased risk of digestive tract cancer, particularly following transplantation. The Division is also part of the PANC4 consortium, which last year published results from large multicenter pooled analyses on the association between a history of allergies or ulcer and pancreatic cancer risk. The division also conducted several meta-analyses and reviews on the association between alcohol drinking and cancers, Vitamin D and overall mortality, use of vitamin supplements and cancer.

     

    During 2013, the Division pursued its research activity on melanoma, through a varieties of studies ranging from the melanoma aetiology, screening, prevention, treatment and outcome. Specific research topics included: sun-bed use, self-examination, surgical treatment, sentinel node biopsy and whole-body diffusion-weighted imaging.

     

    Another research area in which the division had a long-standing interest and reputation includes nutrition. In 2013, special research focus was made on the role of vitamin D, including vitamin D supplementation, on cancer and mortality risk. The Division also conducted a large-scale nutritional survey among heavy smokers enrolled in a lung cancer prevention study and reported on the association between nutrient intake, nutrient pattern, red meat consumption and adherence to the Mediterranean diet and lung cancer risk.

     

    In total, in 2015 (from January to September) the division contributed to 65 articles published on peer-reviewed journals, with an overall impact factor of 255.

     

     

    SPECIFIC RESEARCH PROGRAMS

    FOOD COMPOSITION DATABASE FOR EPIDEMIOLOGICAL STUDIES IN ITALY

    Principal Investigator: Patrizia Gnagnarella (patrizia.gnagnarella@ieo.it)

    The Division is responsible for the Food Composition Database for Epidemiological Studies in Italy, which has become a major instrument for the conduction of National epidemiological nutritional studies. 

    The update of the Food Composition Database for Epidemiological Studies in Italy (BDA) BDA V1-2015 is now available at the website www.bda-ieo.it. In addition to new a graphical interface, this new version includes 978 food items and updated information for the fruit food groups (fresh, cooked fruit, dried fruit, fruit flours and fruit juices). Additional nutrients/food components are included for this food group, not present in the previous edition: aminoacids, fatty acids (also omega-3), simple sugars, Mg, Cu, Se, Cl, I, Mn, S, Pantotenic acid, Biotin, vitamin B12 and vitamin K. Energy values have been recalculated including the contribution of dietary fiber, according to the EU legislation.
    Visit our website www.bda-ieo.it and discover all features!

     

    UNDERSTANDING HOW CANCER STEM CELLS DRIVE BREAST CANCER GROWTH AND HOW TO EXPLOIT THEM AS ITS ACHILLES’ HEEL

    Coordinated by Pier Paolo Di Fiore

    Sub-task: Establishment of a task force for biometrics: Patrick Maisonneuve

    This research program is focused on understanding the mechanisms regulating normal and cancer stem cell asymmetric and symmetric division and how this impacts breast cancer prognosis and treatment. The task of the Division of Epidemiology and Biostatistics is to establish a task-force for biometrics to provide support for the design, analysis and reporting of translational studies on cancer biomarkers.

    The full project is supported by a grant from the Italian Association for Cancer Research (AIRC 5 per 1000).

     

    MELAVID

    Principal Investigator: Sara Gandini

    This research project aims to assess whether vitamin D supplementation could improve prognosis of melanoma. This is an Italian multicentre trial in stage II resected melanoma patients, monitoring changes in 25(OH)D. In short term, we intend to study the biology of VDR and Vitamin D Binding Protein in relation to melanoma prognosis and on vitamin D metabolism, taking into account vitamin D intake. Findings from this study will be of large interest for a wide spectrum of cancers.

    This is a collaborative study carried out in collaboration with the Division of Melanoma and Muscolo-cutaneous Sarcoma and the Division of Prevention and genetics of IEO.

    The project is supported by a grant form the Umberto Veronesi Foundation.

     

    CoViDMicrobiome: Relationship between microbiota, Vitamin D and colorectal cancer

    Principal Investigator: Sara Gandini

    The principal aim is to compare microbiota profiles in patients with colorectal cancer and healthy subjects. Secondary aims are the comparisons of Vitamin D levels, gut flora and vitamin D genes polymorphisms with cancer stage and proliferation.

    We designed a case-control study to evaluate differences of bacterial composition at baseline by disease status and in association with Vitamin D level. Colorectal cancer patients will be recruited before undergoing surgery. Healthy subjects will be match by age, sex, body mass index and season. Faecal and serum samples will be collected and analysed by real time PCR and competitive immunochemiluminescent assay. Discovery of a microbiota composition, associated with colorectal cancer and modulated by Vitamin D, might allow identification of pathological mechanisms and definition of new preventive strategies.

    The results might be applicable also for other health conditions since microbiota and Vitamin D are involved in several pathophysiological processes.

    This is a collaborative study carried out in collaboration with the Department of experimental Oncology and the Division of Prevention and genetics of IEO.

    The project is supported by a grant form the Umberto Veronesi Foundation.

     

    M-SKIP

    Principal Investigator: Sara Raimondi

    The M-SKIP project is an international pooled-analysis investigating the role of the pigmentation gene MC1R on skin cancer development, with a specific focus on melanoma. This collaborative project, leading by the Division of Epidemiology and Biostatistics, involves 31 international researchers, around 8000 melanoma, 3000 non-melanoma skin cancer cases and 15000 healthy subjects. The main goal is to investigate the dependent and independent contribution of MC1R gene on skin carcinogenesis by phenotypic characteristics, taking into account the complex interactions between genetic, phenotypic and environmental factors, like sun exposure. To achieve this goal, appropriate statistical methods to assess for interaction, mediation and population heterogeneity have been investigating and applying. The identification of subjects with a markedly high MC1R-associated skin cancer risk will be of particular importance for assessing targeted preventive strategies in a screening setting.

    The project is supported by a grant from the Italian Association for Cancer Research.

     

     

     

  • PUBLICATIONS 2015 (01 jan-21 sep)

    1. Pasquali E, García-Borrón JC, Fargnoli MC, Gandini S, Maisonneuve P, Bagnardi V, Specchia C, Liu F, Kayser M, Nijsten T, Nagore E, Kumar R, Hansson J, Kanetsky PA, Ghiorzo P, Debniak T, Branicki W, Gruis NA, Han J, Dwyer T, Blizzard L, Landi MT, Palmieri G, Ribas G, Stratigos A, Council ML, Autier P, Little J, Newton-Bishop J, Sera F, Raimondi S; for the M-SKIP Study Group. MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: A pooled-analysis from the M-SKIP project. Int J Cancer 2015;136(3):618-31.
    2. Bruno S, Thompson AJ, Critelli R, Crosignani A, Rossi S, De Lisi S, Cariani E, Zermiani P, Vaira V, Boccaccio V, Maisonneuve P, Villa E. Interferon lambda-3 is not associated with clinical outcome in patients with HCV-induced compensated cirrhosis: A long-term cohort study. Antiviral Res 2015;113C:27-32.
    3. Santoro L, Tagliabue M, Massaro MA, Ansarin M, Calabrese L, Giugliano G, Alterio D, Rocca MC, Grosso E, Plànicka M, Benazzo M, Chiesa F. An algorithm to predict postoperative complications in oropharyngeal and oral cavity carcinoma. Head Neck 2015;37(4):548-56.
    4. Petrella F, Radice D, Borri A, Galetta D, Gasparri R, Casiraghi M, Tessitore A, Pardolesi A, Solli P, Veronesi G, Rizzo S, Martella S, Rietjens M, Spaggiari L. Chest wall resection and reconstruction for locally recurrent breast cancer: From technical aspects to biological assessment. Surgeon 2014 Apr 5. pii: S1479-666X(14)00037-7. doi: 10.1016/j.surge.2014.03.001. [Epub ahead of print]
    5. Aurilio G, Graffeo R, Bagnardi V, Nolè F, Adamoli L, Pagani O, Gallerani E, Ferrari B, Pruneri G, Goldhirsch A. Estramustine phosphate sodium in heavily pretreated patients with metastatic breast cancer: a retrospective consecutive case series. Int J Clin Oncol 2015;20(1):90-4.
    6. Pruneri G, Gigli F, Rafaniello Raviele P, Gardellini A, Raimondi S, De Fiori E, Preda L, Viale G, Martinelli G, Laszlo D. Core needle biopsy as a front line diagnostic approach for lymphoma patients. Hematol Oncol 2014 Jul 2. doi: 10.1002/hon.2150. [Epub ahead of print].
    7. Martinelli G, Montoro J, Vanazzi A, Andreola G, Liptrott S, Radice D, Negri M, Preda L, Pruneri G, Laszlo D. Chlorambucil-rituximab as first-line therapy in patients affected by follicular non-Hodgkin's lymphoma: a retrospective single-centre study. Hematol Oncol 2014 Jul 22. doi: 10.1002/hon.2154. [Epub ahead of print]
    8. Berstad P, Løberg M, Larsen IK, Kalager M, Holme O, Botteri E, Bretthauer M, Hoff G. Long-term lifestyle changes after colorectal cancer screening: randomised controlled trial. Gut 2015;64(8):1268-76.
    9. Veronesi G, Travaini LL, Maisonneuve P, Rampinelli C, Bertolotti R, Spaggiari L, Bellomi M, Paganelli G. Positron emission tomography in the diagnostic work-up of screening-detected lung nodules. Eur Respir J 2015;45(2):501-10.
    10. Petralia G, Musi G, Padhani AR, Summers P, Renne G, Alessi S, Raimondi S, Matei DV, Renne SL, Jereczek-Fossa BA, De Cobelli O, Bellomi M. Robot-assisted Radical Prostatectomy: Multiparametric MR Imaging-directed Intraoperative Frozen-Section Analysis to Reduce the Rate of Positive Surgical Margins. Radiology 2014;274(2):434-44.
    11. Bruno S, Bollani S, Zignego AL, Pascasio JM, Magni C, Ciancio A, Caremani M, Mangia A, Marenco S, Piovesan S, Chemello L, Babudieri S, Moretti A, Gea F, Colletta C, Perez-Alvarez R, Forns X, Larrubina JR, Arenas J, Crespo J, Calvaruso V, Ceccherini Silberstein F, Maisonneuve P, Craxì A, Calleja JL; Italian and Spanish (IAS)-BoC Study Group. Undetectable HCV-RNA at treatment-week 8 results in high-sustained virological response in HCV G1 treatment-experienced patients with advanced liver disease: the International Italian/Spanish Boceprevir/Peginterferon/Ribavirin Name Patients Program. J Viral Hepat 2015;22(5):469-80.
    12. De Giorgi V, Grazzini M, Savarese I, Gori A, Papi F, D'Errico A, Scarfì F, Gandini S. The impact of body area in melanoma self-detection: a retrospective study. Eur J Cancer Prev 2015;24(4):343-6.
    13. Monterisi S, D'Ario G, Dama E, Rotmensz N, Confalonieri S, Tordonato C, Troglio F, Bertalot G, Maisonneuve P, Viale G, Nicassio F, Vecchi M, Di Fiore PP, Bianchi F. Mining cancer gene expression databases for latent information on intronic microRNAs. Mol Oncol 2015;9(2):473-87.
    14. Montagna E, Bagnardi V, Viale G, Rotmensz N, Sporchia A, Cancello G, Balduzzi A, Galimberti V, Veronesi P, Luini A, Mastropasqua MG, Casadio C, Sangalli C, Goldhirsch A, Colleoni M. Changes in PgR and Ki-67 in residual tumour and outcome of breast cancer patients treated with neoadjuvant chemotherapy. Ann Oncol 2015;26(2):307-13.
    15. Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, Scotti L, Jenab M, Turati F, Pasquali E, Pelucchi C, Galeone C, Bellocco R, Negri E, Corrao G, Boffetta P, La Vecchia C. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer 2015;112(3):580-93.
    16. Marchegiani G, Malleo G, D'Haese JG, Wenzel P, Keskin M, Pugliese L, Borin A, Benning V, Nilsson L, Oruc N, Segersvard R, Friess H, Schmid R, Löhr M, Maisonneuve P, Bassi C, Ceyhan GO, Salvia R, Del Chiaro M. Association Between Pancreatic IPMNs and Extra-pancreatic Malignancies. Clin Gastroenterol Hepatol 2015;13(6):1162-9.
    17. Maisonneuve P, Lowenfels AB. Risk factors for pancreatic cancer: a summary review of meta-analytical studies. Int J Epidemiol 2015;44(1):186-98.
    18. Intra M, Viale G, Vila J, Grana CM, Toesca A, Gentilini O, Galimberti V, Veronesi P, Luini A, Rotmensz N, Bagnardi V, Mattar D, Colleoni M. Second Axillary Sentinel Lymph Node Biopsy for Breast Tumor Recurrence: Experience of the European Institute of Oncology. Ann Surg Oncol 2015;22(7):2372-7.
    19. Curigliano G, Disalvatore D, Esposito A, Pruneri G, Lazzeroni M, Guerrieri-Gonzaga A, Luini A, Orecchia R, Goldhirsch A, Rotmensz N, Bonanni B, Viale G. Risk of subsequent in situ and invasive breast cancer in human epidermal growth factor receptor 2-positive ductal carcinoma in situ. Ann Oncol 2015;26(4):682-7.
    20. Haugvik SP, Hedenström P, Korsæth E, Valente R, Hayes A, Siuka D, Maisonneuve P, Gladhaug IP, Lindkvist B, Capurso G. Diabetes, Smoking, Alcohol and Family History of Cancer as Risk Factors for Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis. Neuroendocrinology 2015;101(2):133-42.
    21. Rampinelli C, Origgi D, Vecchi V, Funicelli L, Raimondi S, Deak P, Bellomi M. Ultra-low-dose CT with model-based iterative reconstruction (MBIR): detection of ground-glass nodules in an anthropomorphic phantom study. Radiol Med 2015;120(7):611-7.
    22. Veronesi G, Lazzeroni M, Szabo E, Brown PH, DeCensi A, Guerrieri-Gonzaga A, Bellomi M, Radice D, Grimaldi MC, Spaggiari L, Bonanni B. Long-term effects of inhaled budesonide on screening-detected lung nodules. Ann Oncol 2015;26(5):1025-30.
    23. Turati F, Galeone C, Gandini S, Augustin LS, Jenkins DJ, Pelucchi C, La Vecchia C. High glycemic index and glycemic load are associated with moderately increased cancer risk. Mol Nutr Food Res 2015;59(7):1384-94.
    24. Leonardi MC, Morra A, Santoro L, Balduzzi A, Ivaldi GB, Vischioni B, Ferrari A, Fodor C, Dell'Acqua V, Cardinale DM, Cipolla C, Luini A, Colleoni M, Jereczek-Fossa BA, Orecchia R. Nonrandomized comparison between concomitant and sequential chemoradiotherapy with anthracyclines in breast cancer. Tumori 2015 Feb 13;0(0):0. doi: 10.5301/je.5000218. [Epub ahead of print]
    25. Vila J, Gandini S, Gentilini O. Overall survival according to type of surgery in young (≤40 years) early breast cancer patients: A systematic meta-analysis comparing breast-conserving surgery versus mastectomy. Breast 2015;24(3):175-81.
    26. Serrano D, Gnagnarella P, Raimondi S, Gandini S. Meta-analysis on vitamin D receptor and cancer risk: focus on the role of TaqI, ApaI, and Cdx2 polymorphisms. Eur J Cancer Prev 2015 Mar 3. [Epub ahead of print]
    27. Ferrucci PF, Minchella I, Mosconi M, Gandini S, Verrecchia F, Cocorocchio E, Passoni C, Pari C, Testori A, Coco P, Munzone E. Dacarbazine in combination with bevacizumab for the treatment of unresectable/metastatic melanoma: a phase II study. Melanoma Res 2015;25(3):239-45.
    28. Caini S, Gibelli B, Palli D, Saieva C, Ruscica M, Gandini S. Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies. Cancer Causes Control 2015;26(4):511-8.
    29. Orsi F, Monfardini L, Bonomo G, Krokidis M, Della Vigna P, Disalvatore D. Ultrasound guided high intensity focused ultrasound (USgHIFU) ablation for uterine fibroids: Do we need the microbubbles? Int J Hyperthermia 2015;31(3):233-9.
    30. Curigliano G, Bagnardi V, Bertolini F, Alcalay M, Locatelli MA, Fumagalli L, Rabascio C, Calleri A, Adamoli L, Criscitiello C, Viale G, Goldhirsch A. Antiangiogenic therapy in recurrent breast cancer with lymphangitic spread to the chest wall: A randomized phase II trial of bevacizumab with sequential or concurrent oral vinorelbine and capecitabine. Breast 2015;24(3):263-71.
    31. de Cobelli O, Terracciano D, Tagliabue E, Raimondi S, Galasso G, Cioffi A, Cordima G, Musi G, Damiano R, Cantiello F, Detti S, Victor Matei D, Bottero D, Renne G, Ferro M. Body mass index was associated with upstaging and upgrading in patients with low-risk prostate cancer who met the inclusion criteria for active surveillance. Urol Oncol 2015;33(5):201.e1-8.
    32. Montani F, Marzi MJ, Dezi F, Dama E, Carletti RM, Bonizzi G, Bertolotti R, Bellomi M, Rampinelli C, Maisonneuve P, Spaggiari L, Veronesi G, Nicassio F, Di Fiore PP, Bianchi F. miR-Test: A Blood Test for Lung Cancer Early Detection. J Natl Cancer Inst 2015;107(6): djv063.
    33. Gnagnarella P, Misotti AM, Santoro L, Akoumianakis D, Del Campo L, De Lorenzo F, Lombardo C, Milolidakis G, Sullivan R, McVie JG. Nutritional Online Information for Cancer Patients: a Randomized Trial of an Internet Communication Plus Social Media Intervention. J Cancer Educ 2015 Mar 31. [Epub ahead of print]
    34. Catania C, Botteri E, Barberis M, Conforti F, Toffalorio F, Marinis FD, Boselli S, Noberasco C, Delmonte A, Spitaleri G, Spaggiari L, Rotmensz N, Passaro A, Bazolli B, Alfieri M, Manzotti M, Fumagalli C, Milani A, De Pas T. Molecular features and clinical outcome of lung malignancies in very young people. Future Oncol 2015;11(8):1211-21.
    35. Pugliese L, Keskin M, Maisonneuve P, D'Haese JG, Marchegiani G, Wenzel P, Del Chiaro M, Ceyhan GO. Increased incidence of extrapancreatic neoplasms in patients with IPMN: Fact or fiction? A critical systematic review. Pancreatology 2015;15(3):209-16.
    36. Chiavari L, Gandini S, Feroce I, Guerrieri-Gonzaga A, Russell-Edu W, Bonanni B, Peccatori FA. Difficult choices for young patients with cancer: the supportive role of decisional counseling. Support Care Cancer 2015 Apr 11. [Epub ahead of print]
    37. Ruscica M, Macchi C, Gandini S, Morlotti B, Erzegovesi S, Bellodi L, Magni P. Free and bound plasma leptin in anorexia nervosa patients during a refeeding program. Endocrine 2015 Apr 12. [Epub ahead of print] No abstract available.
    38. Boniol M, Doré JF, Greinert R, Gandini S, Cesarini JP; Sécurité Solaire and EUROSKIN. Re: exposure to indoor tanning without burning and melanoma risk by sunburn history. J Natl Cancer Inst 2015;107(5).
    39. Fraga-Guedes C, André S, Mastropasqua MG, Botteri E, Toesca A, Rocha RM, Peradze N, Rotmensz N, Viale G, Veronesi P, Gobbi H. Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression. Breast Cancer Res Treat 2015;151(1):131-40.
    40. Aurilio G, Bagnardi V, Nolè F, Pruneri G, Graffeo R, Petit JY, Cullurà D, Martella S, Locatelli M, Iera M, Rey P, Curigliano G, Rotmensz N, Munzone E, Goldhirsch A. Outcome of Immediate Breast Reconstruction in Patients With Nonendocrine-Responsive Breast Cancer: A Monoinstitutional Case-Control Study. Clin Breast Cancer 2015;15(5):e237-41.
    41. Rizzo S, Origgi D, Brambilla S, De Maria F, Foà R, Raimondi S, Colombo N, Bellomi M. Radiation Exposure of Ovarian Cancer Patients: Contribution of CT Examinations Performed on Different MDCT (16 and 64 Slices) Scanners and Image Quality Evaluation: An Observational Study. Medicine (Baltimore) 2015;94(17):e765.
    42. Cancello G, Bagnardi V, Sangalli C, Montagna E, Dellapasqua S, Sporchia A, Iorfida M, Viale G, Barberis M, Veronesi P, Luini A, Intra M, Goldhirsch A, Colleoni M. Phase II Study With Epirubicin, Cisplatin, and Infusional Fluorouracil Followed by Weekly Paclitaxel With Metronomic Cyclophosphamide as a Preoperative Treatment of Triple-Negative Breast Cancer. Clin Breast Cancer 2015;15(4):259-65.
    43. Maisonneuve P, Shivappa N, Hébert JR, Bellomi M, Rampinelli C, Bertolotti R, Spaggiari L, Palli D, Veronesi G, Gnagnarella P. Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study. Eur J Nutr 2015 May 8. [Epub ahead of print]
    44. Rizzo S, Petrella F, Buscarino V, De Maria F, Raimondi S, Barberis M, Fumagalli C, Spitaleri G, Rampinelli C, De Marinis F, Spaggiari L, Bellomi M. CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer. Eur Radiol 2015 May 9. [Epub ahead of print]
    45. Petit JY, Maisonneuve P, Rotmensz N, Bertolini F, Clough KB, Sarfati I, Gale KL, Macmillan RD, Rey P, Benyahi D, Rietjens M. Safety of Lipofilling in Patients with Breast Cancer. Clin Plast Surg 2015;42(3):339-44.
    46. Waterhouse M, Risch HA, Bosetti C, Anderson KE, Petersen GM, Bamlet WR, Cotterchio M, Cleary SP, Ibiebele T, La Vecchia C, Skinner H, Strayer L, Bracci PM, Maisonneuve P, Bueno-de-Mesquita HB, Zatoński W, Lu L, Yu H, Janik-Koncewicz K, Neale RE; Pancreatic Cancer Case-Control Consortium (PanC4). Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium. Ann Oncol 2015; 26(8):1776-83.
    47. Casiraghi M, Maisonneuve P, Brambilla D, Petrella F, Solli P, Guarize J, De Marinis F, Spaggiari L. The role of extended pulmonary metastasectomy. J Thorac Oncol 2015;10(6):924-9.
    48. Ferrucci PF, Gandini S, Battaglia A, Alfieri S, Di Giacomo AM, Giannarelli D, Cappellini GC, De Galitiis F, Marchetti P, Amato G, Lazzeri A, Pala L, Cocorocchio E, Martinoli C. Baseline neutrophil-to-lymphocyte ratio is associated with outcome of ipilimumab-treated metastatic melanoma patients. Br J Cancer 2015;112(12):1904-10.
    49. Bonello L, Preda L, Conte G, Giannitto C, Raimondi S, Ansarin M, Maffini F, Summers P, Bellomi M. Squamous cell carcinoma of the oral cavity and oropharynx: what does the apparent diffusion coefficient tell us about its histology? Acta Radiol 2015 May 26. pii: 0284185115587734. [Epub ahead of print]
    50. Del Piccolo L, Pietrolongo E, Radice D, Tortorella C, Confalonieri P, Pugliatti M, Lugaresi A, Giordano A, Heesen C, Solari A; AutoMS Project. Patient Expression of Emotions and Neurologist Responses in First Multiple Sclerosis Consultations. PLoS One 2015;10(6):e0127734.
    51. Gorini A, Mazzocco K, Gandini S, Munzone E, McVie G, Pravettoni G. Development and psychometric testing of a breast cancer patient-profiling questionnaire. Breast Cancer (Dove Med Press) 2015;7:133-46.
    52. Bertani E, Falconi M, Grana C, Botteri E, Chiappa A, Misitano P, Spada F, Ravizza D, Bazolli B, Fazio N. Small intestinal neuroendocrine tumors with liver metastases and resection of the primary: prognostic factors for decision making. Int J Surg 2015;20:58-64.
    53. Tagliabue E, Fargnoli MC, Gandini S, Maisonneuve P, Liu F, Kayser M, Nijsten T, Han J, Kumar R, Gruis NA, Ferrucci L, Branicki W, Dwyer T, Blizzard L, Helsing P, Autier P, García-Borrón JC, Kanetsky PA, Landi MT, Little J, Newton-Bishop J, Sera F, Raimondi S. MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project. Br J Cancer 2015;113(2):354-63.
    54. Sammassimo S, Pruneri G, Andreola G, Montoro J, Steffanoni S, Nowakowski GS, Gandini S, Negri M, Habermann TM, Raderer M, Li ZM, Zinzani PL, Adam P, Zucca E, Martinelli G. A retrospective international study on primary extranodal marginal zone lymphoma of the lung (BALT lymphoma) on behalf of International Extranodal Lymphoma Study Group (IELSG). Hematol Oncol 2015 Jul 7. doi: 10.1002/hon.2243. [Epub ahead of print]
    55. Arnaboldi P, Santoro L, Mazzocco K, Oliveri S, Maggioni A, Pravettoni G. The Paradox of Pelvic Exenteration: The Interaction of Clinical and Psychological Variables. Int J Gynecol Cancer 2015 Aug 4. [Epub ahead of print]
    56. Montagna E, Bagnardi V, Rotmensz N, Viale G, Cancello G, Palazzo A, Galimberti V, Veronesi P, Luini A, Mastropasqua MG, Santillo B, Goldhirsch A, Colleoni M. Outcome and Medial Presentation of Breast Cancer: European Institute of Oncology Experience. Clin Breast Cancer 2015 Jul 10. pii: S1526-8209(15)00149-4. doi: 10.1016/j.clbc.2015.07.003. [Epub ahead of print]
    57. Bazzi C, Tagliabue E, Raimondi S, Rizza V, Casellato D, Nangaku M. High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy. Int J Nephrol 2015;2015:730234.
    58. Sanchini V, Bonizzi G, Disalvatore D, Monturano M, Pece S, Viale G, Di Fiore PP, Boniolo G. A Trust-Based Pact in Research Biobanks. From Theory to Practice. Bioethics 2015 Aug 26. doi: 10.1111/bioe.12184. [Epub ahead of print]
    59. Pelosi G, Fabbri A, Papotti M, Rossi G, Cavazza A, Righi L, Tamborini E, Perrone F, Settanni G, Busico A, Testi MA, Maisonneuve P, De Braud F, Garassino M, Valeri B, Sonzogni A, Pastorino U. Dissecting pulmonary large cell carcinoma by targeted next generation sequencing of several cancer genes pushes genotypic-phenotypic correlations to emerge. J Thorac Oncol 2015 Aug 26. [Epub ahead of print]
    60. Tagliabue E, Raimondi S, Gandini S. Vitamin D, Cancer Risk, and Mortality. Adv Food Nutr Res 2015;75:1-52. (BOOK CHAPTER)
    61. Caini S, Raimondi S, Johansson H, De Giorgi V, Zanna I, Palli D, Gandini S. Telomere length and the risk of cutaneous melanoma and non-melanoma skin cancer: a review of the literature and meta-analysis. J Dermatol Sci 2015 Aug 22. pii: S0923-1811(15)30038-4. doi:0.1016/j.jdermsci.2015.08.003. [Epub ahead of print] Review.
    62. Balduzzi A, Bagnardi V, Sandri MT, Dellapasqua S, Cardillo A, Montagna E, Cancello G, Iorfida M, Ghisini R, Viale G, Intra M, Luini A, Goldhirsch A, Colleoni M. Intermittent Letrozole Administration as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive Early Breast Cancer: A Biologic Study. Clin Breast Cancer 2015;15(5):e257-62.
    63. Tagliabue E, Raimondi S, Gandini S. Meta-analysis of vitamin D-binding protein and cancer risk. Cancer Epidemiol Biomarkers Prev 2015 Sep 12. pii: cebp.0262.2015. [Epub ahead of print]
    64. Boniol M, Autier P, Gandini S. Melanoma mortality following skin cancer screening in Germany. BMJ Open 2015;5(9):e008158.
    65. De Lorenzi F, Hubner G, Rotmensz N, Bagnardi V, Loschi P, Maisonneuve P, Venturino M, Orecchia R, Galimberti V, Veronesi P, Rietjens M. Oncological results of oncoplastic breast-conserving surgery: Long term follow-up of a large series at a single institution: A matched-cohort analysis. Eur J Surg Oncol 2015 Sep 8. pii: S0748-7983(15)00732-5. doi: 10.1016/j.ejso.2015.08.160. [Epub ahead of print]

UN PICCOLO GESTO E' PER NOI UN GRANDE AIUTO

PARTNERSHIP

Università degli Studi di Milano Ecancer Medical Science IFOM-IEO Campus

ACCREDITAMENTI

Ministero della Salute Joint Commission International Breastcertification bollinirosa

© 2013 Istituto Europeo di Oncologia - via Ripamonti 435 Milano - P.I. 08691440153

IRCCS - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

facebook IEO googleplus IEO twitter IEO pinterest IEO vimeo IEO