Un istituto di riferimento dove la ricerca sui tumori diventa cura in tempo reale

Research in my group deals with the structural and functional characterization of mechanisms underlying fundamental biological processes, with a particular emphasis on mitotic spindle orientation and asymmetric stem cell divisions. Our long-term interest is to build accurate molecular models of how mitotic processes are executed, in order to understand how they become deregulated under pathological conditions. To obtain molecular information, we employ a multi-disciplinary approach involving forefront methods of structural biology (mainly X-ray crystallography), biochemistry, biophysics, and cell biology.

Current Position

• 2009 – pres. Assistant Professor. Department of Experimental Oncology, IEO, Milan (It).

Appointment

• 2005 – 2008 Staff Scientist. European Institute of Oncology, Milan (It).

Education

• 2001 – 2004 Post-doctoral fellow. European Institute of Oncology, Milan (It).
• 1996 – 2000 PhD in Crystallography: Birkbeck College, University of London.
• 1996 – 2000 Training at the EMBL of Heidelberg and Hamburg (De).
• 1990 –1995 Degree in Physics: University of Milan (summa cum laude) Milan (It).

• Carminati M., Gallini S., Pirovano L., Alfieri A., Bisi S. and Mapelli M. (2016) Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation. Nat. Struct. Mol. Biol., 23,155-63.
• Gallini S., Carminati M., De Mattia F., Pirovano L., Martini E., Oldani A., Asteriti I.A., Guarguaglini G, Mapelli M. (2016) NuMA phosphorylation orchestrates spindle orientation. Current Biol., 26, 458-69.
• Santoro A, Vlachou T, Carminati M, Pelicci PG, Mapelli M. (2016) Molecular mechanisms of asymmetric divisions in mammary stem cells. EMBO Rep., 17, 1700-1720.
• Andersen D.S., Colombani J., Palmerini V., Chakrabandhu K., Röthlisberger M., Toggweiler J., Basler K., Mapelli M., Hueber A., and Léopold P. (2015) The Drosophila TNF receptor Grindelwald couples loss of cell polarity with neoplastic growth. (2015) Nature, 522, 482-6.
• Culurgioni S., Alfieri A., Pendolino V., Laddomada F. and Mapelli M. (2011) Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. P.N.A.S., 108, 20998-1003.

All publication in pdf file attached