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  • Infermieri Area Critica

    L’Istituto Europeo di Oncologia, al fine di assicurare la corretta realizzazione dell’attività clinica assegnata, sta cercando Infermieri da inserire in Area Critica e Blocco Operatorio.

     I/le candidati/e ideali possiedono il diploma di Infermiere Professionale ovvero il diploma di laurea in Scienze Infermieristiche, sono interessati e motivati a fornire assistenza personalizzata e di qualità in un contesto la cui organizzazione ruota intorno alle necessità del paziente, inteso non solo come malato, ma soprattutto come essere umano, ed è finalizzata all’eccellenza del servizio.

     Sono dotati di spirito di iniziativa, autonomia, problem solving, flessibilità, buone capacità organizzative e di relazione interpersonale, predisposizione al lavoro in team.

    Si richiede un buon orientamento al servizio, inteso come motivazione alla comprensione delle necessità del paziente e al soddisfacimento dei suoi bisogni.

     Le candidature verranno valutate per diverse tipologie contrattuali.

    Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL10.

  • Infermieri area degenza

    L’Istituto Europeo di Oncologia, al fine di assicurare la corretta realizzazione dell’attività clinica assegnata, sta cercando Infermieri da inserire nelle aree di Degenza Medica e Degenza Chirurgica.

      

    I/le candidati/e ideali possiedono il diploma di Infermiere Professionale ovvero il diploma di laurea in Scienze Infermieristiche, sono interessati e motivati a fornire assistenza personalizzata e di qualità in un contesto la cui organizzazione ruota intorno alle necessità del paziente, inteso non solo come malato, ma soprattutto come essere umano, ed è finalizzata all’eccellenza del servizio.
     
    Sono dotati di spirito di iniziativa, autonomia, problem solving, flessibilità, buone capacità organizzative e di relazione interpersonale, predisposizione al lavoro in team.

      

    Si richiede un buon orientamento al servizio, inteso come motivazione alla comprensione delle necessità del paziente e al soddisfacimento dei suoi bisogni.

      

    E’ previsto un percorso formativo di elevato livello in un contesto fortemente innovativo.

     

    L'offerta contrattuale è idonea a soddisfare candidature anche di elevata esperienza e professionalità.

     

    Le candidature verrano valutate per diverse tipologie contrattuali.

      

    Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16a: servizio.selezione@ieo.it citando il rif: 2019SEL13.

     

     

  • INFERMIERE DI RICERCA

    L’Istituto Europeo di Oncologia, IRCCS con sede in Milano ricerca un Infermiere di Ricerca.

     Si richiede Laurea in Scienze Infermieristiche, il Master di ricerca costituirà un titolo preferenziale.

    È richiesta un’ottima conoscenza del pacchetto office.

    Indispensabile una buona conoscenza della lingua inglese, in particolare scritta.

     E’ gradita un’esperienza in ambito oncologico.

     Le risorse, ricoprendo un ruolo nuovo e innovativo, verranno inserite in un contesto stimolante e in continua evoluzione che prevede un network internazionale e una collaborazione tra diverse figure professionali nell’ottica di una collaborazione interdisciplinare.

     Se sei dinamico, motivato, dotato di spirito di iniziativa, flessibile, con buone capacità organizzative e di relazione interpersonale e ti piace lavorare in team puoi inviare il tuo CV aggiornato e corredato di autorizzazione al trattamento dei dati personali ai sensi del D.Lgs. 196/03, a: servizio.selezione@ieo.it – Rif2019Sel 14

    Le candidature verranno valutate per diverse tipologie contrattuali.

     

     

     

     

     

     

     

  • MEDICO SPECIALISTA IN GINECOLOGIA E OSTETRICIA

    L’ Istituto Europeo di Oncologia sta ricercando un medico specialista in ginecologia e ostetricia da inserire all’interno dell’Unità di Ginecologia Preventiva.

     

    Il/la candidato/a ideale possiede la Laurea in Medicina e Chirurgia ed è specializzato/a in Ginecologia. Ha un’esperienza nella gestione delle patologie HPV correlate e del basso tratto genitourinario, comprovata dal numero di esami diagnostici eseguiti (colposcopie, vulvoscopie) e delle procedure chirurgiche ambulatoriali e DH eseguite (conizzazione e isteroscopie).  

     

    L’esperienza nell’esecuzione di ecografie ginecologiche di primo livello ed esperienza in ginecologia oncologica, costituiranno un titolo preferenziale.

     

    Completano il profilo spirito d’iniziativa, autonomia e propensione al lavoro d’equipe.

     

    Si offre un contratto libero professionale rinnovabile.

     

    Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL12.

     

  • MEDICO SPECIALISTA IN EMATOLOGIA

    L’ Istituto Europeo di Oncologia sta ricercando un medico specialista in ematologia da inserire all’interno dell’Unità di Oncoematologia.

     

    Il/la candidato/a ideale possiede la Laurea in Medicina e Chirurgia ed è specializzato/a in Ematologia.

     

    L’Istituto vorrebbe incontrare candidati realmente motivati a garantire un’alta qualità terapeutica/assistenziale nonché relazionale verso i pazienti, che abbiano interesse al costante aggiornamento professionale e scientifico e all’attività di documentazione in linea con la propria Divisione.

    Il ruolo richiede spirito di iniziativa, autonomia e problem solving.

    È previsto un piano di sviluppo e formazione di elevato livello in un contesto fortemente innovativo.

    Completano il profilo spirito d’iniziativa, autonomia e propensione al lavoro d’equipe.

     

    Si offre un contratto libero professionale.

     

    Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL14

  • SPECIALISTA FUNDRAISING E AREA EVENTI

    Siamo alla ricerca di una figura da inserire all’interno dell’Ufficio Raccolta Fondi Fondazione IEO-CCM.

    In particolare la risorsa si dedicherà alla gestione e allo sviluppo dell’area Eventi al fine di raccogliere fondi da destinare ai progetti di Ricerca dell’Istituto Europeo di Oncologia e del Centro Cardiologico Monzino e di rafforzare la brand awarness della Fondazione sul territorio lombardo e nazionale.

    La figura gestirà in autonomia e sotto la supervisione del Responsabile della raccolta fondi e comunicazione tutti gli eventi promossi direttamente dalla Fondazione e quelli promossi dagli stakeholders della Fondazione e degli Istituti sul territorio nazionale.

    Nello specifico dovrà svolgere prevalentemente le seguenti mansioni:

    -      Ideazione e organizzazione degli eventi di raccolta fondi e di divulgazione promossi direttamente dalla Fondazione;

    -      Coordinamento, supporto e supervisione degli eventi promossi sul territorio dagli stakeholders della Fondazione e degli Istituti;

    -      Gestione e sviluppo delle relazioni con partner Corporate, testimonial, istituzioni, volontari e media;

    -      Contatto e gestione dei fornitori coinvolti nell’organizzazione e nella promozione degli eventi stessi

    -      Reportistica periodica e quadratura con contabilità interna relativi alle attività dell’area di competenza;

    -      Coordinamento e condivisione periodica con tutte le aree dell’ufficio e con l’Ufficio Stampa della Fondazione.

    Il/la candidato ideale ha un’esperienza pregressa nell’ambito del fundraising e nello specifico degli eventi di almeno 5 anni, una forte motivazione e adesione alla mission della Fondazione IEO-CCM, un forte interesse per il fundraising e una buona conoscenza del pacchetto office.  

    Completano il profilo ottime capacità di relazione interpersonale, organizzazione del lavoro, autonomia operativa, precisione e rispetto dei tempi e delle scadenze. Capacità di operare multitasking e sotto stress.

    Disponibilità a brevi trasferte.

    RAL e tipologia contrattuale commisurate all’esperienza.

    Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL16

  • ADDETTO CONTABILITA' GENERALE E TESORERIA

    Il Gruppo IEO-CCM, per i propri Ospedali IRCCS con sede a Milano, cerca Addetto Contabilità generale e tesoreria, da inserire all’interno della Direzione Centrale Amministrazione, Finanza e Controllo.

     La/Il candidata/o svolgerà principalmente le seguenti attività:

     –     Registrazioni contabili tramite SAP;

    –     Attività di riconciliazione delle schede contabili, riconciliazioni bancarie e quadrature casse;

    –     Supporto nei processi di acquisto e pagamenti fornitori;

    –     Supporto nei i processi mensili di chiusura iva e pagamento tributi.

     La/Il candidata/o ideale ha un’esperienza pregressa di almeno due anni in ruolo analogo, in contesto aziendale mediamente strutturato e/o studio commercialista.

    È laureato in economia, ha una buona conoscenza della lingua inglese, ottima conoscenza del pacchetto Office (MS Word, MS Excel, MS PowerPoint).

    Caratteristiche aggiuntive che completano il profilo sono: problem solving, buone capacità organizzative e di relazione interpersonale; flessibilità, orientamento al servizio e un’eccellente capacità di lavorare in team con altre funzioni e ruoli.

    Si offre a contratto a tempo indeterminato.

     Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL17.

Consulta la bacheca delle offerte di borsa di studio qui di seguito:

  • BANDO BORSA RADIOLOGO

    L’Istituto Europeo di Oncologia bandisce una borsa di studio annuale di Euro 27.000 annui lordi destinata ad un medico neo specializzato in radiodiagnostica interessato a lavorare all’interno della Divisione di Radiologia per lo sviluppo del progetto di ricerca:

     

    “Radiomica e radiogenomica dei tumori polmonari non a piccole cellule: relazione della firma radiomica con mutazioni genetiche e implicazioni per le terapie emergenti”.

     

    E’ richiesta una buona conoscenza della lingua inglese e un buon track record di attività scientifica.

     

    Il ruolo richiede spirito d’iniziativa in ambito scientifico e propensione al mantenimento di un buon clima di collaborazione tra le diverse figure professionali presenti nell’Unità organizzativa.

     

     Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16a: servizio.selezione@ieo.it citando il rif: 2018BO10.

  • BANDO BORSA BIOLOGO/BIOTECNOLOGO

    L’Istituto europeo di oncologia bandisce una Borsa di Studio di €22.000 per la durata di dodici mesi destinata ad un Biologo/Biotecnologo interessato a lavorare in stretta collaborazione con la divisione di Radioterapia a la Biobank for Translational Medicine Unit (B4MED), Dipartimento di Patologia e Medicina di Laboratorio.

    Il candidato sarà inserito nelle attività di ricerca previste dal progetto “Studio randomizzato di fase II per il trattamento delle metastasi linfonodali e ossee da tumore prostatico oligo-ricorrente con radioterapia stereotassica (SBRT) +/- terapia ormonale (RADIOSA TRIAL)”, finanziato dall’AIRC.

    Il candidato ideale, che riporta al direttore della Divisione di radioterapia, dovrà essere in possesso dei seguenti requisiti:

    - laurea magistrale in Biologia o Biotecnologie;

    -  con esperienza in biologia cellulare e molecolare e istologia.

    - ottima conoscenza dei principali strumenti di office.

    - ottima conoscenza della lingua inglese, con particolare attenzione alla capacità di scrittura di report scientifici e di lavori da sottomettere a riviste internazionali.

    Ogni altro titolo (master, dottorato, corsi) ed esperienza professionale nel settore della ricerca preferibilmente in radioterapia-radiologia-oncologia (pubblicazioni scientifiche, progetti di ricerca) costituiscono un titolo preferenziale.

    Il ruolo richiede spirito di iniziativa, autonomia e problem solving. È inoltre indispensabile una forte propensione al team work e uno spiccato orientamento alla collaborazione tra le diverse figure professionali.

    Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16a: servizio.selezione@ieo.it citando il rif:2019BOR05

  • Borsa Medico Radioterapista

    La Fondazione IEO CCM bandisce una borsa di studio annuale di Euro 27.000,00 lordi destinata a Medici specializzati in Radioterapia interessati a lavorare all’interno della Divisione di Radioterapia per lo sviluppo del progetto “Radioterapia intraoperatoria (IORT) del carcinoma mammario: elaborazione di un nomogramma per la IORT in base ai dati delle pazienti trattate presso l’Istituto Europeo di Oncologia”.

     

    E’ richiesta una buona conoscenza della lingua inglese.

     

    Il/la candidato/a ideale è motivato a garantire un’alta qualità terapeutica/assistenziale e a portare avanti una ricerca clinica relativa alla IORT.

    Il ruolo richiede spirito di iniziativa in ambito scientifico e propensione al mantenimento di un buon clima di collaborazione tra le diverse figure professionali presenti nell’Unità organizzativa.

     

     

    Le domande, corredate di cv aggiornato e copia del titolo di studio, dovranno pervenire entro il 25/09/2018 al seguente indirizzo di posta elettronica:

    servizio.selezione@ieo.it - citando il rif. 2018BOR03

     

  • Postdoc in Structural Biology of Stem Cell division

    The team of Marina Mapelli at the European Institute of Oncology IEO of Milano (Italy) is recruiting a postdoctoral researcher to investigate mechanisms of Wnt-signaling in stem cell asymmetric divisions in the intestinal crypts, and their implication in cancer development. The position is immediately available within a project funded by AIRC and the Italian Ministry of Health.

     

    We are looking for a candidate with a strong background in structural biology, with particular interest in crystallography or Cryo-Electron Microscopy techniques, and good experience in biochemistry of large macromolecular assemblies.

     

    The project will explore fundamental questions on mechanisms of cell proliferation, stem cell asymmetry, and fate decision. To gain molecular information, research in our lab integrates biochemistry and structural biology with cell biology of intestinal cells. Experimental approaches such as biochemistry, structural biology, and cell biology of mitosis are well established in the lab (Culurgioni & Mari, Nat. Comm. 2018; Carminati, NSMB 2016; Gallini, Curr. Biol. 2016), and additional techniques of stem cell manipulation and imaging in intestinal organoids are being developed collaboratively.

    For more information about the lab please visit: http://project132468.tilda.ws/

     

    The recruited Postdoctoral fellow will be integrated in the Mapelli lab, at the IEO Department of Experimental Oncology based at the IFOM-IEO Campus (Milan, IT), which provides an excellent environment at the interface between structural biology, cell biology and cancer genetics. The working language in the lab is English. The researchers will receive a salary and health/social security coverage from the IEO. The contract will be initially for one or two years, with possible extensions until the end of the project. The starting date is negotiable.

     

    This call has an open deadline, applications will be examined until the position is filled. Potential applicants are encouraged to contact Marina Mapelli as early as possible, sending a brief description of interests, a CV, and contact information of three references to marina.mapelli@ieo.it.

  • POSTDOCTORAL POSITION in APPLIED BIOINFOMATICS

    One postdoctoral position (applied bioinformatics) available in the group of Prof PG Pelicci at the Department of Experimental Oncology (DEO), European Institute of Oncology (IEO), Milan.

     

    The lab of prof Pelicci at the DEO of IEO has one open position as postdoctoral fellow in applied bioinformatics. Main interest of the lab is the investigation of cancer-associated molecular mechanisms, with a strong focus on (gen)omic approaches and clinical data analyses.

    The ideal candidate should have prior experience in the analysis of large genomic and epigenomic datasets. The applicants must have excellent analytical skills, a strong statistical background, ability to work independently and as part of a team, very good oral/written communication and interpersonal skills to efficiently interact with collaborators, and write and/or contribute to research reports and publications for peer-reviewed journals.

    Candidates should have a PhD degree or equivalent in any of biology, bioinformatics, maths, statistics, computer science or engineering, beside a testified large experience in NGS data analysis, applied to genetics or epigenetics studies. The applicant should have strong programming skills (Python, Perl, C++ or Java) and confidence with statistical analysis softwares such as R or Matlab.

    Candidates must be fluent in both spoken and written English.

     

    Send curriculum and contact information to: piergiuseppe.pelicci@ieo.it

  • Positions in computational biology / bioinformatics

    The lab of Martin Schaefer is now recruiting two early-career scientists with a strong computational background. We are looking for talented and interested candidates on either pre- or postdoctoral level. Predoctoral candidates will be first hired on a temporary fellowship and are expected to apply to the SEMM PhD call 2019. Postdocs will receive a three year fellowship (1+2).
    The aim of the open positions is to further the understanding of cancer evolution by developing methods that allow to identify cancer driver events beyond point mutations (such as epigenetic changes) and to apply these methods to experimental and clinical data. More details on the research interests of the lab can be found here: schaeferlab.org
    Candidates should have expertise in statistics, programming and the analysis of molecular cancer data. In particular, we encourage researchers with interest in either network biology or population genetics to apply.  
    The European Institute of Oncology is one of Europe’s leading cancer research institutes in a central location of Milan and hosts an international research community. It provides postgraduate education through the European School of Molecular Medicine SEMM with a PhD program in Systems Medicine.
    For more information or for sending an application (which should include a CV, cover letter, expected availability date, a list of publications and contact details of 2 - 3 referees) please contact: martin.schaefer@ieo.it

  • Postdoctoral position

    Job description

    We seek a highly motivated scientist to fill a postdoctoral position in the Pier Paolo Di Fiore laboratory at the European Institute of Oncology (IEO) in Milan for a project focused on epigenetic modifications involved in cancer progression, in particular in bladder and breast cancer. The candidate will design, execute, and interpret research involving techniques and fundamental molecular and cellular biology research tools to investigate the role of epigenetic alterations of candidate tumor suppressor genes and oncogenes in the biology of human and mouse bladder and breast cancer.


    This project will involve the use of standard molecular and cellular biology techniques in addition to techniques associated with epigenetic studies, including chromatin immunoprecipitation assays (ChIP) and ChIP-seq as well as comprehensive gene expression analyses, molecular manipulations of target gene expression using viral vectors, and functional analyses in cell lines, primary cells, stem cells and mouse disease models.


    Desired skills and experience:

    The successful candidate should have a PhD with a strong background in molecular biology, cell biology, chromatin and histone biology, genomics, and/or biochemistry. Previous training in epigenetic molecular techniques is required as well as extensive experience in cell culture. Research experience in bioinformatics analysis, primary cells and stem cell manipulation, 3D-organoids culture and animal models would be advantageous.


    Interested applicants should submit a letter of application, CV, and references to:


    Daniela Tosoni, PhD (daniela.tosoni@ieo.it),

    Salvatore Pece, MD (salvatore.pece@ieo.it)

  • Postdoc in Stem Cell Biology

    Position description

    The laboratory of Pier Paolo di Fiore at IEO is seeking an outstanding and highly motivated candidate with training in stem cell biology and/or energy metabolism for a postdoctoral Research Fellow position in the field of Stem Cell Biology, Metabolism and Metastasis. The successful candidate will work on funded projects to define how dysfunction in mitochondrial dynamics and/or metabolic pathways regulate fate specification of normal stem cells, as well as the ability of cancer stem cell to drive tumor progression. Specifically, the project will employ metabolomics and metabolic pathway analysis to investigate the involvement of specific oncogenic pathways in the selection of clones of cancer stem cells responsible for tumor progression towards metastasis.

    Desired skills and experience:

    The applicant must have a Ph.D., M.D., or equivalent doctoral degree in a field related to the project, with significant laboratory experience. Background in cellular metabolism is required. Experience in molecular biology including molecular cloning, DNA, RNA and protein work and extensive cell culture is also required. Research experience in bioinformatics, including RNA/DNA-seq analysis also at the single cell level, primary cells and stem cell manipulation, 3D-organoids culture and animal models is preferred. Background in cancer biochemistry, signalling and genetics will be considered favourably.

     

     

    Interested applicants should submit a letter of application, CV, and references to:


    Daniela Tosoni, PhD (daniela.tosoni@ieo.it)

     

    Salvatore Pece, MD (salvatore.pece@ieo.it)

  • Bioinformatic position

    The Cancer Genomics working group of the Alleanza contro il Cancro national network is seeking a motivated bioinformaticians for positions based at the European Institute of Oncology (IEO) in Milan

    BACKGROUND

    Alleanza Contro il Cancro (ACC) is the largest oncology network in Italy, with 22 participating institutions devoted to oncological research producing more than 5000 publications/year with a normalized impact factor of > 20k, with > 4000 researchers and thousands of active clinical trials. Activity within ACC is conducted under the framework of 6 pathology-oriented working groups (WG breast, glioblastoma, colon, melanoma, lung and sarcoma tumors) and 2 cross-disciplinary WG (genomics and immuno-oncology). Specifically, the aim of the ACC genomics WG is to foster the integration of high throughput next generation sequencing in clinical diagnostic workflow, with a particular focus on identifying inovative methodologies that maximize clinically relevant information and provide genomics data interpretation.

    ACC genomics recently launched multiple projects in which large DNA/RNA sequencing panels are applied to prospectively recruited cancer patients, in collaboration with the 6 pathology-oriented WGs. The first pilot project, currently up and running, aims at sequencing germline and somatic genomes from 1000 prospectively recruited non-small cell lung cancer patients, with several ancillary projects (liquid biopsy, immuno-oncology biomarkers, and others). Additional projects have been designed and are due to open in 2018. The current sequencing platform is aimed at characterizing single nucleotide variants and structural alterations using medium-sized (0.8-3 Mb) targeted sequencing, but ongoing projects are aimed at developing methodologies to detect additional parameters (mutational burden, mismatch repair defects, mutational signatures) and at testing new sequencing methodologies (long-read sequencing, HLA typing, TCR clonality, RNAseq from FFPE clinical specimens, etc)

    A dedicated bioinformatic infrastructure has been built in collaboration with Elixir/CINECA, and a network of bioinformaticians within participating institutions has been formed (ACC bioinformatics). The group periodically meets and works in collaboration to develop dedicated analytical pipelines for the project.

     

    ACC genomics is seeking a motivated bioinformatician to coordinate the bioinformatics efforts within the multiple projects. The candidate will be based at the IEO in Milan, where he/she will also interact with one of the largest computational biology communities in Italy

    This is an excellent opportunity to conduct cutting-edge bioinformatics in the clinical field and to pioneer the emerging field of clinical bioinformatics.  

     

    RESPONSIBILITIES

    • Perform routine analyses of clinical samples with next-generation sequencing (NGS);
    • Participate in designing, implementing, validating and maintaining bioinformatics pipelines;
    • Contribute to bioinformatics process optimization and standardization;
    • Participate to the development of scientific databases and their application in a growing clinical genomics environment;
    • Implement, update and maintain locally stored data resources required for various analysis tasks;
    • Writing bioinformatics protocols and documentation;
    • BSc. or MSc. in Bioinformatics-related subject (biology, bioinformatics, mathematics, statistics, physics, etc.);
    • Programming skills (Python, R,  preferable);
    • Experience with NGS data analysis;
    • Proficiency with Unix/Linux operating system;
    • Good English level;
    • Attention to details;
    • Ability to multitask, work and learn independently, and be self-motivated;
    • Ability to work in team and desire to collaborate with other bioinformaticians in the group is essential;
    • A strong work ethic and commitment to timely delivery of results.

    ESSENTIAL REQUIREMENTS

    • BSc. or MSc. in Bioinformatics-related subject (biology, bioinformatics, mathematics, statistics, physics, etc.);
    • Programming skills (Python, R,  preferable);
    • Experience with NGS data analysis;
    • Proficiency with Unix/Linux operating system;
    • Good English level;
    • Attention to details;
    • Ability to multitask, work and learn independently, and be self-motivated;
    • Ability to work in team and desire to collaborate with other bioinformaticians in the group is essential;
    • A strong work ethic and commitment to timely delivery of results.

    PREFERRED QUALIFICATIONS

    • Ph.D. in Bioinformatics or equal experience;
    • Experience with genomics data analysis;
    • Prior experience working with large-scale datasets using high performance computing environments is desirable.
    • Experience with Cancer genomics and bioinformatics related resources (TCGA, ICGC, COSMIC, etc.)
    • experience with database construction and maintenance

     

     

    For further info or to arrange an informal interview, please write to: luca.mazzarella@ieo.it

     

     

     

  • Bioinformatic Postdoc Position

    The candidate will join a team coordinated by dr Luca Mazzarella and will operate at the interface between clinical and basic research to explore molecular mechanisms of cancer pathogenesis and therapeutic resistance, with a highly multidisciplinary approach

    Specific interests in the lab are

    -the interplay between chromatin and metabolism in cancer biology and immuno-therapy (Mazzarella et al Blood 2015 126:459, Rossi et al Science Adv 2016)

    -the development of novel computational tools for the usage and interpretation of genomic data (see Melloni et al, Genome Med 2014, Breast Cancer Res Treat 2017, JCO Prec Oncol 2018)

    -the exploration of resistance mechanisms to novel therapeutics in breast and ovarian cancers.

    -the elucidation of molecular mechanisms underlying myeloproliferative neoplasms (MPN). On this topic, the lab was recently awarded a grant to elucidate genetic alterations associated with "triple-negative" and familial MPN, using novel long-read sequencing technologies (linked reads by 10x genomics, Nanopore sequencing), in collaboration with the University of Pavia, host to one of the largest existing collections of MPN samples.

     

    The candidate shall operate within the IEO campus and in contact with the Clinical Genomics unit at IEO, within a large and expanding bioinformatics community. Available state-of-the-art facilities include Illumina Novaseq and HiSeq, ION Torrent S5, 10x Chromium, Oxford Nanopore sequencers.

    The applicant must have excellent analytical skills, a strong statistical background, ability to work independently and as part of a team, very good oral/written communication and interpersonal skills to efficiently interact with the experimental collaborators and write and/or contribute to production of research reports and publications for peer reviewed journals.

     

    Required skills are:

    • A PhD-level background in a related discipline. Candidates with non-biological background, including Computer Science, Engineering, Mathematics, Statistics or Physics, are strongly encouraged to apply
    • Experience in software and algorithm development
    • Proficiency in the R environment
    • Strong programming skills in at least one of the following languages: Python, Perl, Java, C++
    • Proficiency in Unix/Linux operating systems
    • Familiarity with High-Performance Computing
    • Experience with analysis of large genomics datasets. Specific experience on Whole Exome/Genome Sequencing is desirable but by no means required

     

    For further info or to arrange an informal interview, please write to

    luca.mazzarella@ieo.it

     

  • POSTDOCTORAL POSITION IN COMPUTATIONAL CANCER BIOLOGY

    We are looking for a highly motivated postdoctoral fellow to join the new computational cancer biology lab of Martin Schaefer at the European Institute of Oncology (IEO) in Milan. The position is funded by a 5 year AIRC grant to Martin Schaefer.

     

    We aim to develop an understanding of cancer as a complex and evolving system. The aim of this position is to study the interaction of tumor cells with the local microbiome and other components of the microenvironment. The project will involve developing computational methods for the analysis of sequencing data and applying them to multi-omics data from clinical and laboratory samples.

     

    Candidates should hold a PhD (in a relevant area), have expertise in statistics, programming and the analysis of omics data and have a basic understanding of human molecular biology. Knowledge of data science techniques such as machine learning and being familiar with concepts of tumor evolution are a plus.

     

    More information on the lab of Martin Schaefer can be found at www.schaeferlab.org.

     

    For more information on the position or for sending an application (which should include a CV, cover letter, a list of publications and contact details of 2 - 3 referees) please contact: martin.schaefer@ieo.it. The position is available immediately but the starting date can be negotiated. 

     

  • Postdoc in molecular oncology at the Department of Experimental Oncology, IEO, Milan

    The candidate will be jointly supervised by Prof Piergiuseppe Pelicci and Dr Luca Mazzarella to explore molecular mechanisms of acute myeloid leukemias (AML).

    The lab is extensively exploring the interaction between systemic metabolism (modulated by obesity, caloric restriction, intermittent fasting), chromatin dynamics and the regulation of protein quality control (ER stress, UPR) in mouse models of AML, a research project stemming from clinical observations (Breccia, Mazzarella et al Blood 2012).

    In particular, we have intensively investigated the biology of the FLT3 kinase, the most commonly mutated gene in AML. We have found that the most frequent genetic alterations involving FLT3 perturb the phyisological folding, maturation and intracellular localization of the protein. This causes global alterations in cellular metabolism which may be favoured by specific dietary components, and creates vulnerabilities that could be targeted pharmacologically.

    The candidate will be asked to pursue a research program aimed at exploring the biology of mutant FLT3 using a combination of imaging, transcriptomics, proteomics and metabolomics techniques.

     

    The candidate will join a growing and stimulating research environment at the interface between the clinics and the lab, in a research institute of excellence with state-of-the-art equipment for

    • DNA/RNA sequencing (Illumina Novaseq and Hiseq, Chromium 10x, Nanopore MinIon and GridIon sequencers). In particular the institute has accumulated wide experience on single-cell sequencing (largest center in Italy by volume)
    • imaging, with multiple confocal microscopies (Leica DM6-B, SP8-CSU, SP8-FSU, TIRF) and equipment for live cell-imaging
    • flow cytometry with 3 analyzers (2 FacsCelesta, 1 MACSQuant) and 3 cell sorters (FACSMelody, FacsAria Fusion and FacsJazz)
    • proteomics/metabolomics unit equipped with a Q Exactive HF hybrid quadrupole-Orbitrap mass spectrometer coupled with a EASY-nLC 1200 Ultra-HPLC chromatography

    Requirements:

    • PhD-level background in biology, medicine or biotechnology
    • Documented experience with in vivo mouse models for molecular oncology (specific experience in hematology is highly desirable)
    • Familiarity with flow cytometry and fluorescence microscopy
    • Documented experience in at least one of the following: RNAseq, signal transduction analysis, metabolomics, proteomics, endoplasmic reticulum biology
    • Ability to work independently and as part of a team
    • Very good oral/written communication and interpersonal skills
    • Ability to independently write research reports and publications for peer reviewed journals

     

    For further info or to arrange an informal interview, please write to

    luca.mazzarella@ieo.it

     

  • Postdoctoral fellowship “Nuclear proteomics”

    One postdoctoral fellowship is immediately available in the Bonaldi Group “Nuclear proteomics”, at the Department of Experimental Oncology at the European Institute of Oncology in Milan, to develop a project focused on the molecular characterisation of the protein-methyl-proteome by MS approaches and the assessment of the functional role of protein-methylation in various cellular processes.  

    We are looking for an enthusiastic, motivated person, with a proven track record in biochemistry, or molecular and cellular biology. Demonstrated ability in interpersonal communication and collaboration, as well as strong initiative and ability to work independently, to drive the project forward are essential.  

     

    The post-doctoral fellow will work in a AIRC-funded project, we cutting-edge proteomics approaches will be designed and implemented for the in- depth analysis of the extent and dynamics of the human methyl-proteome, in response to various external cues and to its pharmacological modulation by epigenetics drugs.

     

    Requirements: PhD in one of the following discipline: Biology, Molecular Biology, Biochemistry, Molecular Medicine. Strong motivation and research commitment; excellent analytical and organization skill; a background in MS-based proteomics is highly appreciated, even though not essential.

    Competitive salaries will depend on the candidate’s track record and experience.

    The operating language of the lab is English.

    The position is up to three years.

     

    The European Institute of Oncology is one of Europe’s most influential cancer research institutes. The IEO operates as a Comprehensive Cancer Center, linking fundamental and applied research to clinical activities, patient care and clinical trials. The department of Experimental Oncology (DEO) is currently composed of ~250 scientists working in 15 independent research groups and units. DEO is located within a scientific campus together with two other partner institutions: the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT). The IEO is one of the 13 members of the EU-LIFE alliance to promote excellence in life sciences in Europe.

     

    IEO is an equal opportunity employer committed to excellence through diversity.

     

    Applicants should contact Dr. Tiziana Bonaldi, sending an e-mail with a brief description of interests and a CV at: tiziana.bonaldi@ieo.it.

    Application deadline: June 1st 2019

     

    https://www.ieo.it/en/RESEARCH/People/Researchers/Bonaldi-Tiziana/

  • POST-DOCTORAL POSITION IN EPIGENETIC MECHANISMS IN STEM CELL DIFFERENTIATION AND ONCOGENESIS UNIT

    POST-DOCTORAL POSITION IN EPIGENETIC MECHANISMS IN STEM CELL DIFFERENTIATION AND ONCOGENESIS UNIT

     

    A post-doctoral position in the Research Group of Prof. Diego Pasini at the European Institute of Oncology (IEO, Milan). The position will be filled as soon as we have identified the ideal candidate.

     

    We are seeking ambitious and hard-working candidates for a project focused at characterizing chromatin remodelling activities in stem cells and adult tissue homeostasis under physiological and oncogenic conditions. The research activity will take place at the Department of Experimental Oncology, a highly competitive, international and scientifically stimulating environment, and will involve the use of genetic, biochemical, transcriptomic and epigenomic approaches applied to stem cell, in vivo genetic mouse models as well as 3D organoids models derived from compound mice or patient samples.

     

    Desired qualifications

    Candidates with a Ph.D. in life sciences and skills in molecular and cellular biology are invited to apply. Proven experience with mouse handling, histology, in vitro 3D cultures, chromatin biology and NGS-related approaches will be an added advantage. Proficient English, independent working capacity, excellent organizational and collaborative skills are key requirements. Candidates are expected to be self-motivated research scientists driven by scientific curiosity and proactive in developing personal lines of research on the topic of the group.

     

    A competitive salary will be offered depending on experience.

     

    Application details

    Applicants should summit a brief motivation letter, CV, and contact details for two referees to: Dr. Karin Ferrari (karinjohanna.ferrari@ieo.it).

     

    For more info

    Website: https://www.ieo.it/en/RESEARCH/People/Researchers/Pasini-Diego/

    Research Gate: https://www.researchgate.net/profile/Diego_Pasini

    Full publication list (PubMed): https://www.ncbi.nlm.nih.gov/pubmed/?term=Diego+Pasini

  • Postdoctoral position in the Laboratory of Genome Integrity

    A post-doctoral position is available in the Laboratory of Genome Integrity at the European Institute of Oncology (Milan, Italy) led by Dr. Stefano Santaguida. We seek a highly motivated candidate interested in studying the consequences of chromosome segregation errors on cell physiology. By applying a number of highly integrative cutting-edge techniques (e.g., CRISPR/Cas9 gene-editing, mass spectrometry), the succesful candidate will study how untransformed and cancer cells with imbalanced chromosome numbers are recognized and cleared by immune cells.

     

    Qualifications:

     

    ·       Strong interest in chromosome segregation, cell cycle and cancer biology

    ·       Technical expertise with molecular biology, cell biology (e.g., immunofluorescence, flow cytometry, time-lapse microscopy) and cell culture techniques

     

    ·       Able to work both independently and as part of a laboratory team

    ·       A recent PhD in molecular, cellular or cancer biology

    The position will be initially for one year with possible extensions up to three years         

     

    Salary will be commensurate with experience                                                                             

     

    Starting date: September 2019

     

    Find more about the work of the Santaguida Lab at www.santaguidalab.org

  • Postdoctoral Fellow Position

    A Postdoctoral Fellow position is available at theEuropean Institute of Oncology - Department of Experimental Oncology, in the laboratory of Dr Giuliana Pelicci.
    Specific interest of the laboratory includes understanding the role of LSD1 in glioblastoma. We are seeking a talented and committed researcher to contribute to deciphering the mechanism of resistance toward anti-LSD1 therapies. Highly motivated individuals (Ph.D. or M.D.) with track record of productivity in brain tumors and cancer stem cells biology are encouraged to apply. The position is reserved to candidates who want to gain experience in translational research. The successful applicant must have experience in experimental research, including OMICs technologies and cancer biology. Candidates have to be highly organized and able to work independently. Salary will be commensurate with experience.
    In order to apply, please send a letter with a personal statement describing your scientific accomplishments and career goals, a complete CV  and two reference letters to giuliana.pelicci@ieo.it

  • Postdoctoral position

    A postdoctoral position, funded by the Italian Association for Cancer Research (AIRC), is available to join the T cell Metabolism Unit led by Dr. Teresa Manzo at IRCCS European Institute of Oncology, IEO in Milan (Italy).

     

    About us.

    Our laboratory is interested in understanding the link between T cell metabolism and immunity in cancer. We have recently discovered that tumor microenvironment drives CD8+ T cell exhaustion by depleting nutrients that are fundamental for sustaining their effector activity. We are now studying how these metabolic constrains impact T cell functionality and exploring new ways to engineer CD8+ T cells to improve their metabolic fitness.

     

    The Research Project.

    The project aims at generating mechanistic understanding of the metabolic reprogramming of tumor-infiltrating T cells. As part of the project the candidate will: 1) identify new mechanisms that lead to metabolically exhausted CD8+ T cells 2) increase their metabolic fitness by (epi) genetic-editing 3) broaden this new immune-therapeutic approach to a wide range of refractory malignancies. These studies will open new opportunities to improve clinical efficacy of cancer immunotherapy.

    Research activity will be based at the Department of Experimental Oncology within IRCCS European Institute of Oncology, a forefront research Institute in Europe, and the candidate will benefit from a dynamic and collaborative research environment, access to state of-the-art research facilities and a competitive salary, commensurate to qualifications and experience.

     

    The candidate.

     

    We are looking for an enthusiastic scientist at the postdoctoral level who will join the team aiming to aims to develop new immunotherapy strategies and broaden their efficacy to a wide range of refractory malignancies. The position is to be filled immediately and is initially for one year, with possibility of extension up to four years. The candidate is a talented and motivated individual with a PhD degree and documented research accomplishments in Immunology, Molecular Biology and/or Epigenetic (certified by first author publications). The candidate will have general experience in immunological assay, cancer biology and/or molecular biology, sound technical skills and general experience in mouse modeling and hands-on experience with Multi-parametric Flow Cytometry and FACS analysis. The candidate will be able to work independently and as part of a team, and will have strong organizational, written and verbal communication skills.

     

    Join us

    for great quality of science and great quality of life ‐ the IEO Campus is one of the main research hubs in Europe. Our working language is English.

     

    For application:

    Send a curriculum vitae detailing current research interests, a brief motivation letter together with contact details for three references to Teresa Manzo (teresa.manzo@ieo.it).

     

    Key words.

    Immunology, metabolism, epigenetic.

     

    Key references.

     

    • Manzo T, Kristin Anderson, Boone Prentice, Schalck Aislyn, Raman Ayush, Karen C Dwyer, Sara Tucci, Caterina Bartolacci, Kenneth Dunner, Andrea Raimondi, McClure Marissa, Reyzer Michelle, Pier Paolo Scaglioni, Carlo Tacchetti, Richard M. Caprioli, Michael P Kim, Nicholas E. Navin, Jennifer Wargo, Phil Greenberg, Luigi Nezi* and Giulio Draetta*. Metabolic exhaustion of  CD8+ T cells is driven by lipid accumulation in the pancreas tumor microenvironment. Under revision.
    • Manzo T, Sturmheit T, Basso V, Petrozziello E, Hess Michelini R, Freschi M, Protti MP, Schumacher T, Debets R, Swartz MA, Corti A, Bellone M, Mondino A. Alloreactive T cell-induced intratumoral TNF-a warrants therapeutic efficacy to TCR engineered T cells in the cure of solid tumors. Cancer Res, 2016. 
    • Veliça P, Zech M, Henson S, Holler A, Manzo T, Pike R, Santos E Sousa P, Zhang L, Heinz N, Schiedlmeier B, Pule M, Stauss H, Chakraverty R. Genetic regulation of fate decisions in therapeutic T cells to enhance tumor protection and memory formation. Cancer Res, 2015 
    • Buchan SL*, Manzo T*, Flutter B, Rogel A, Edwards N, Zhang L, Sivakumaran S, Ghorashian S, Carpenter B, Bennett CL, Freeman GJ, Sykes M, Croft M, Al-Shamkhani A, Chakraverty R. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. *Co-First author J Immunol, 2015 
    • Manzo T, Michelini RH, Sturmheit T, Basso V, Bellone M, Mondino A. Tumor-targeting vaccination instructs graft-vs.-tumor immune responses. Oncoimmunology, 2013. 

     

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