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  • Infermieri Area Critica

    L’Istituto Europeo di Oncologia, al fine di assicurare la corretta realizzazione dell’attività clinica assegnata, sta cercando Infermieri da inserire in Area Critica e Blocco Operatorio.

     

    I/le candidati/e ideali possiedono il diploma di Infermiere Professionale ovvero il diploma di laurea in Scienze Infermieristiche, sono interessati e motivati a fornire assistenza personalizzata e di qualità in un contesto la cui organizzazione ruota intorno alle necessità del paziente, inteso non solo come malato, ma soprattutto come essere umano, ed è finalizzata all’eccellenza del servizio.

     

    Sono dotati di spirito di iniziativa, autonomia, problem solving, flessibilità, buone capacità organizzative e di relazione interpersonale, predisposizione al lavoro in team.

    Si richiede un buon orientamento al servizio, inteso come motivazione alla comprensione delle necessità del paziente e al soddisfacimento dei suoi bisogni.

     

    E’ richiesta un'esperienza minima nell'area di almeno 3 anni.

     

    L’offerta contrattuale è idonea a soddisfare candidature anche di elevata esperienza e professionalità.

     

    Chi fosse interessato, può inviare il proprio cv aggiornato al seguente indirizzo e-mail: servizio.selezione@ieo.it citando il rif. 18SEL16

  • Infermieri area degenza

    L’Istituto Europeo di Oncologia, al fine di assicurare la corretta realizzazione dell’attività clinica assegnata, sta cercando Infermieri da inserire nelle aree di Degenza Medica e Degenza Chirurgica.

      

    I/le candidati/e ideali possiedono il diploma di Infermiere Professionale ovvero il diploma di laurea in Scienze Infermieristiche, sono interessati e motivati a fornire assistenza personalizzata e di qualità in un contesto la cui organizzazione ruota intorno alle necessità del paziente, inteso non solo come malato, ma soprattutto come essere umano, ed è finalizzata all’eccellenza del servizio.
     
    Sono dotati di spirito di iniziativa, autonomia, problem solving, flessibilità, buone capacità organizzative e di relazione interpersonale, predisposizione al lavoro in team.

      

    Si richiede un buon orientamento al servizio, inteso come motivazione alla comprensione delle necessità del paziente e al soddisfacimento dei suoi bisogni.

      

    E’ previsto un percorso formativo di elevato livello in un contesto fortemente innovativo.

     

    L'offerta contrattuale è idonea a soddisfare candidature anche di elevata esperienza e professionalità.

     

    RAL e inquadramento contrattuale saranno definiti in base all’effettiva esperienza maturate.

      

    Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16a: servizio.selezione@ieo.it citando il rif: 2018SEL14

     

  • INFERMIERE DI RICERCA

    L’Istituto Europeo di Oncologia, IRCCS con sede in Milano ricerca un Infermiere di Ricerca.

     Si richiede Laurea in Scienze Infermieristiche, il Master di ricerca costituirà un titolo preferenziale.

    È richiesta un’ottima conoscenza del pacchetto office.

    Indispensabile una buona conoscenza della lingua inglese, in particolare scritta.

     E’ gradita un’esperienza in ambito oncologico.

     Le risorse, ricoprendo un ruolo nuovo e innovativo, verranno inserite in un contesto stimolante e in continua evoluzione che prevede un network internazionale e una collaborazione tra diverse figure professionali nell’ottica di una collaborazione interdisciplinare.

     Se sei dinamico, motivato, dotato di spirito di iniziativa, flessibile, con buone capacità organizzative e di relazione interpersonale e ti piace lavorare in team puoi inviare il tuo CV aggiornato e corredato di autorizzazione al trattamento dei dati personali ai sensi del D.Lgs. 196/03, a: servizio.selezione@ieo.it – Rif2018SEL08

     RAL e inquadramento contrattuale saranno definiti in base all’effettiva esperienza maturate. 

     

     

     

     

     

     

  • MEDICO SPECIALISTA CHIRURGIA PLASTICA

    L’Istituto Europeo di Oncologia ricerca un medico specialista da inserire all’interno della Divisione di Chirurgia Plastica.

     Il/la candidato/a ideale, che riporta al Direttore di Divisione Clinica, è in possesso di laurea in Medicina e Chirurgia, specializzazione in Chirurgia Plastica e Ricostruttiva, iscrizione all’albo e ha maturato tra i 3 e i 5 anni d'esperienza.

    Necessaria la conoscenza della lingua inglese.

     L’Istituto vorrebbe incontrare candidati realmente motivati a garantire un’alta qualità terapeutica/assistenziale nonché relazionale verso i pazienti, che abbiano interesse al costante aggiornamento professionale e scientifico e all’attività di documentazione in linea con la propria Divisione.

    Il ruolo richiede spirito di iniziativa, autonomia e problem solving.

    Indispensabile la propensione al mantenimento di un buon clima di collaborazione tra le diverse figure professionali presenti nella divisione.

     È previsto un piano di sviluppo e formazione di elevato livello in un contesto fortemente innovativo.

     Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL08.

     

  • Medico Radiologo

     

    L’Istituto Europeo di Oncologia ricerca un medico specializzato in radiodiagnostica interessato a lavorare all’interno della Divisione di Radiologia.

     

    E’ richiesta una buona conoscenza della lingua inglese e un buon track record di attività scientifica.

     

    Il ruolo richiede spirito d’iniziativa in ambito scientifico e propensione al mantenimento di un buon clima di collaborazione tra le diverse figure professionali presenti nell’Unità organizzativa.

     

    Si offre un contratto libero professionale.

     

     Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16a: servizio.selezione@ieo.it citando il rif: 2019SEL03.

     

     

     

     

     

  • INFERMIERE EPIDEMIOLOGO

     

     L’Istituto Europeo di Oncologia, IRCCS con sede in Milano ricerca un Infermiere Epidemiologo.

     

    Si richiede Laurea magistrale in Scienze Infermieristiche o Master in sorveglianza e controllo delle infezioni correlate all'assistenza sanitaria o esperienza seppur breve nell'ambito. 

     

    Requisiti:

    -        ottima conoscenza del pacchetto office;

    -        buona conoscenza nella sorveglianza epidemiologia e controllo delle infezioni correlate all’assistenza sanitaria ed in igiene ambientale (controlli microbiologici aria e acqua; legionella e gestione);

    -        dimestichezza nell’uso software di analisi statistica (es. Epi Info, SPSS, R, Stata, SAS);

    -        buona conoscenza della lingua inglese, in particolare scritta;

    -        ottima conoscenza delle banche dati in ambito medico (es. PubMed, Embase) e delle modalità di ricerca bibliografica.

     

    È gradita un’esperienza in ambito oncologico.

     

    Completano il profilo un’alta motivazione, spirito di iniziativa, flessibilità, buone capacità organizzative e interpersonali.

     

    La risorsa verrà inserita nell’area della Direzione Sanitaria in un contesto di costante collaborazione con diverse figure professionali.

     

    RAL e inquadramento contrattuale saranno definiti in base all’effettiva esperienza maturate. Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL08

  • SVILUPPATORE

    L’Istituto Europeo di Oncologia, IRCCS con sede in Milano ricerca uno Sviluppatore Full Stack.

     Il candidato ideale ha un’esperienza di almeno 1-2 anni nella programmazione, lato client e server; competenze elevate nella progettazione e sviluppo di software Full Stack.

     Buona conoscenza di HTML, JavaScript e CSS.

     Costituirà titolo preferenziale una buona conoscenza della lingua inglese.

     Completano il profilo ottime capacità di problem solving, ambizione, curiosità e proattività.

     Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16 a: servizio.selezione@ieo.it citando il rif: 2019SEL01.

     

     

Consulta la bacheca delle offerte di borsa di studio qui di seguito:

  • BANDO BORSA RADIOLOGO

    L’Istituto Europeo di Oncologia bandisce una borsa di studio annuale di Euro 27.000 annui lordi destinata ad un medico neo specializzato in radiodiagnostica interessato a lavorare all’interno della Divisione di Radiologia per lo sviluppo del progetto di ricerca:

     

    “Radiomica e radiogenomica dei tumori polmonari non a piccole cellule: relazione della firma radiomica con mutazioni genetiche e implicazioni per le terapie emergenti”.

     

    E’ richiesta una buona conoscenza della lingua inglese e un buon track record di attività scientifica.

     

    Il ruolo richiede spirito d’iniziativa in ambito scientifico e propensione al mantenimento di un buon clima di collaborazione tra le diverse figure professionali presenti nell’Unità organizzativa.

     

     Le persone interessate, ambosessi (L. 903/77), possono inviare il proprio CV, corredato di autorizzazione al trattamento dei dati personali ai sensi dell’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16a: servizio.selezione@ieo.it citando il rif: 2018BO10.

  • Borsa Medico Radioterapista

    La Fondazione IEO CCM bandisce una borsa di studio annuale di Euro 27.000,00 lordi destinata a Medici specializzati in Radioterapia interessati a lavorare all’interno della Divisione di Radioterapia per lo sviluppo del progetto “Radioterapia intraoperatoria (IORT) del carcinoma mammario: elaborazione di un nomogramma per la IORT in base ai dati delle pazienti trattate presso l’Istituto Europeo di Oncologia”.

     

    E’ richiesta una buona conoscenza della lingua inglese.

     

    Il/la candidato/a ideale è motivato a garantire un’alta qualità terapeutica/assistenziale e a portare avanti una ricerca clinica relativa alla IORT.

    Il ruolo richiede spirito di iniziativa in ambito scientifico e propensione al mantenimento di un buon clima di collaborazione tra le diverse figure professionali presenti nell’Unità organizzativa.

     

     

    Le domande, corredate di cv aggiornato e copia del titolo di studio, dovranno pervenire entro il 25/09/2018 al seguente indirizzo di posta elettronica:

    servizio.selezione@ieo.it - citando il rif. 2018BOR03

     

  • Postdoc in Structural Biology of Stem Cell division

    The team of Marina Mapelli at the European Institute of Oncology IEO of Milano (Italy) is recruiting a postdoctoral researcher to investigate mechanisms of Wnt-signaling in stem cell asymmetric divisions in the intestinal crypts, and their implication in cancer development. The position is immediately available within a project funded by AIRC and the Italian Ministry of Health.

     

    We are looking for a candidate with a strong background in structural biology, with particular interest in crystallography or Cryo-Electron Microscopy techniques, and good experience in biochemistry of large macromolecular assemblies.

     

    The project will explore fundamental questions on mechanisms of cell proliferation, stem cell asymmetry, and fate decision. To gain molecular information, research in our lab integrates biochemistry and structural biology with cell biology of intestinal cells. Experimental approaches such as biochemistry, structural biology, and cell biology of mitosis are well established in the lab (Culurgioni & Mari, Nat. Comm. 2018; Carminati, NSMB 2016; Gallini, Curr. Biol. 2016), and additional techniques of stem cell manipulation and imaging in intestinal organoids are being developed collaboratively.

    For more information about the lab please visit: http://project132468.tilda.ws/

     

    The recruited Postdoctoral fellow will be integrated in the Mapelli lab, at the IEO Department of Experimental Oncology based at the IFOM-IEO Campus (Milan, IT), which provides an excellent environment at the interface between structural biology, cell biology and cancer genetics. The working language in the lab is English. The researchers will receive a salary and health/social security coverage from the IEO. The contract will be initially for one or two years, with possible extensions until the end of the project. The starting date is negotiable.

     

    This call has an open deadline, applications will be examined until the position is filled. Potential applicants are encouraged to contact Marina Mapelli as early as possible, sending a brief description of interests, a CV, and contact information of three references to marina.mapelli@ieo.it.

  • POSTDOCTORAL POSITION in APPLIED BIOINFOMATICS

    One postdoctoral position (applied bioinformatics) available in the group of Prof PG Pelicci at the Department of Experimental Oncology (DEO), European Institute of Oncology (IEO), Milan.

     

    The lab of prof Pelicci at the DEO of IEO has one open position as postdoctoral fellow in applied bioinformatics. Main interest of the lab is the investigation of cancer-associated molecular mechanisms, with a strong focus on (gen)omic approaches and clinical data analyses.

    The ideal candidate should have prior experience in the analysis of large genomic and epigenomic datasets. The applicants must have excellent analytical skills, a strong statistical background, ability to work independently and as part of a team, very good oral/written communication and interpersonal skills to efficiently interact with collaborators, and write and/or contribute to research reports and publications for peer-reviewed journals.

    Candidates should have a PhD degree or equivalent in any of biology, bioinformatics, maths, statistics, computer science or engineering, beside a testified large experience in NGS data analysis, applied to genetics or epigenetics studies. The applicant should have strong programming skills (Python, Perl, C++ or Java) and confidence with statistical analysis softwares such as R or Matlab.

    Candidates must be fluent in both spoken and written English.

     

    Send curriculum and contact information to: piergiuseppe.pelicci@ieo.it

  • Bioinformatic post doctoral position

    BIONFORMATIC POST-DOCTORAL FELLOW POSITION

     

    One bioinformatic post doctoral position, associated with a three-year fellowship (1+2), is now available in the Proteomics Unit at the Department of Experimental Oncology, IEO, Milan, starting Sept/Oct 2018. The Proteomics Unit is primarily dedicated to Mass Spectrometry (MS)-based quantiative proteomics studies applied to the investgiation of molecular oncology mechanisms and has as a long-term focus the development of an innovative anaytical platform for clinical proteomics, in close collaboration with the Nuclear Proteomics Research group directed by Tiziana Bonaldi.

     

    The laboratory is located in the Department of Experimental Oncology of the European Institute of Oncology (IEO), a Comprehensive Cancer Center that couples cancer treatment of fundamental and applied research, based on state-of-the-art research laboratories and clinical facilities, fully equipped, relying on dedicated and trained personnel.

     

    We are seeking a highly motivated young scientist, with strong bioinformatics skills and a publication (in peer-reviewed journals) record of accomplishment. The candidate will work in the Proteomics Unit, to generate high-quality quantitative data and integrate and analyze -omics datasets, working as part of a team, but independently with limited supervision.

    RESPONSIBILITIES

    • Apply computational methods and develop tools to analyse proteomic (MS) data and contribute to interprete the results, in order to discern clinical or biological insights
    • Think independently about new results and communicate new ideas to the team frequently and effectively
    • Collaborate with others members of the Unit and of the Research Group to develop new methods and tools that support research objectives
    • Prepare, deliver presentations; communicate his/her results through manuscripts/abstracts, etc
    • Programming skills (Python, R, Perl  preferable)
    • Proficiency with Unix/Linux operating system
    • Ability to think independently about new results, and formulate novel and testable hypotheses to obtain information on clinical or biological insights
    • Ability to read and critically evaluate scientific literature related to team projects
    • Good English level
    • The familiarity with MS fundamentals and associated data (discovery and targeted LC-MS) will be considered as a plus, but it is not a pre-requisite for consideration.

    REQUIREMENTS

     

    Salary scale will be defined, based on the seniority and expertise of the candidate.

     

    Candidates will send an email with their CV, accompanied by a motivation letter and two references, to tiziana.bonaldi@ieo.it

  • Positions in computational biology / bioinformatics

    The lab of Martin Schaefer is now recruiting two early-career scientists with a strong computational background. We are looking for talented and interested candidates on either pre- or postdoctoral level. Predoctoral candidates will be first hired on a temporary fellowship and are expected to apply to the SEMM PhD call 2019. Postdocs will receive a three year fellowship (1+2).
    The aim of the open positions is to further the understanding of cancer evolution by developing methods that allow to identify cancer driver events beyond point mutations (such as epigenetic changes) and to apply these methods to experimental and clinical data. More details on the research interests of the lab can be found here: schaeferlab.org
    Candidates should have expertise in statistics, programming and the analysis of molecular cancer data. In particular, we encourage researchers with interest in either network biology or population genetics to apply.  
    The European Institute of Oncology is one of Europe’s leading cancer research institutes in a central location of Milan and hosts an international research community. It provides postgraduate education through the European School of Molecular Medicine SEMM with a PhD program in Systems Medicine.
    For more information or for sending an application (which should include a CV, cover letter, expected availability date, a list of publications and contact details of 2 - 3 referees) please contact: martin.schaefer@ieo.it

  • Postdoctoral position

    Job description

    We seek a highly motivated scientist to fill a postdoctoral position in the Pier Paolo Di Fiore laboratory at the European Institute of Oncology (IEO) in Milan for a project focused on epigenetic modifications involved in cancer progression, in particular in bladder and breast cancer. The candidate will design, execute, and interpret research involving techniques and fundamental molecular and cellular biology research tools to investigate the role of epigenetic alterations of candidate tumor suppressor genes and oncogenes in the biology of human and mouse bladder and breast cancer.


    This project will involve the use of standard molecular and cellular biology techniques in addition to techniques associated with epigenetic studies, including chromatin immunoprecipitation assays (ChIP) and ChIP-seq as well as comprehensive gene expression analyses, molecular manipulations of target gene expression using viral vectors, and functional analyses in cell lines, primary cells, stem cells and mouse disease models.


    Desired skills and experience:

    The successful candidate should have a PhD with a strong background in molecular biology, cell biology, chromatin and histone biology, genomics, and/or biochemistry. Previous training in epigenetic molecular techniques is required as well as extensive experience in cell culture. Research experience in bioinformatics analysis, primary cells and stem cell manipulation, 3D-organoids culture and animal models would be advantageous.


    Interested applicants should submit a letter of application, CV, and references to:


    Daniela Tosoni, PhD (daniela.tosoni@ieo.it),

    Salvatore Pece, MD (salvatore.pece@ieo.it)

  • Postdoc in Stem Cell Biology

    Position description

    The laboratory of Pier Paolo di Fiore at IEO is seeking an outstanding and highly motivated candidate with training in stem cell biology and/or energy metabolism for a postdoctoral Research Fellow position in the field of Stem Cell Biology, Metabolism and Metastasis. The successful candidate will work on funded projects to define how dysfunction in mitochondrial dynamics and/or metabolic pathways regulate fate specification of normal stem cells, as well as the ability of cancer stem cell to drive tumor progression. Specifically, the project will employ metabolomics and metabolic pathway analysis to investigate the involvement of specific oncogenic pathways in the selection of clones of cancer stem cells responsible for tumor progression towards metastasis.

    Desired skills and experience:

    The applicant must have a Ph.D., M.D., or equivalent doctoral degree in a field related to the project, with significant laboratory experience. Background in cellular metabolism is required. Experience in molecular biology including molecular cloning, DNA, RNA and protein work and extensive cell culture is also required. Research experience in bioinformatics, including RNA/DNA-seq analysis also at the single cell level, primary cells and stem cell manipulation, 3D-organoids culture and animal models is preferred. Background in cancer biochemistry, signalling and genetics will be considered favourably.

     

     

    Interested applicants should submit a letter of application, CV, and references to:


    Daniela Tosoni, PhD (daniela.tosoni@ieo.it)

     

    Salvatore Pece, MD (salvatore.pece@ieo.it)

  • Bioinformatic position

    The Cancer Genomics working group of the Alleanza contro il Cancro national network is seeking a motivated bioinformaticians for positions based at the European Institute of Oncology (IEO) in Milan

    BACKGROUND

    Alleanza Contro il Cancro (ACC) is the largest oncology network in Italy, with 22 participating institutions devoted to oncological research producing more than 5000 publications/year with a normalized impact factor of > 20k, with > 4000 researchers and thousands of active clinical trials. Activity within ACC is conducted under the framework of 6 pathology-oriented working groups (WG breast, glioblastoma, colon, melanoma, lung and sarcoma tumors) and 2 cross-disciplinary WG (genomics and immuno-oncology). Specifically, the aim of the ACC genomics WG is to foster the integration of high throughput next generation sequencing in clinical diagnostic workflow, with a particular focus on identifying inovative methodologies that maximize clinically relevant information and provide genomics data interpretation.

    ACC genomics recently launched multiple projects in which large DNA/RNA sequencing panels are applied to prospectively recruited cancer patients, in collaboration with the 6 pathology-oriented WGs. The first pilot project, currently up and running, aims at sequencing germline and somatic genomes from 1000 prospectively recruited non-small cell lung cancer patients, with several ancillary projects (liquid biopsy, immuno-oncology biomarkers, and others). Additional projects have been designed and are due to open in 2018. The current sequencing platform is aimed at characterizing single nucleotide variants and structural alterations using medium-sized (0.8-3 Mb) targeted sequencing, but ongoing projects are aimed at developing methodologies to detect additional parameters (mutational burden, mismatch repair defects, mutational signatures) and at testing new sequencing methodologies (long-read sequencing, HLA typing, TCR clonality, RNAseq from FFPE clinical specimens, etc)

    A dedicated bioinformatic infrastructure has been built in collaboration with Elixir/CINECA, and a network of bioinformaticians within participating institutions has been formed (ACC bioinformatics). The group periodically meets and works in collaboration to develop dedicated analytical pipelines for the project.

     

    ACC genomics is seeking a motivated bioinformatician to coordinate the bioinformatics efforts within the multiple projects. The candidate will be based at the IEO in Milan, where he/she will also interact with one of the largest computational biology communities in Italy

    This is an excellent opportunity to conduct cutting-edge bioinformatics in the clinical field and to pioneer the emerging field of clinical bioinformatics.  

     

    RESPONSIBILITIES

    • Perform routine analyses of clinical samples with next-generation sequencing (NGS);
    • Participate in designing, implementing, validating and maintaining bioinformatics pipelines;
    • Contribute to bioinformatics process optimization and standardization;
    • Participate to the development of scientific databases and their application in a growing clinical genomics environment;
    • Implement, update and maintain locally stored data resources required for various analysis tasks;
    • Writing bioinformatics protocols and documentation;
    • BSc. or MSc. in Bioinformatics-related subject (biology, bioinformatics, mathematics, statistics, physics, etc.);
    • Programming skills (Python, R,  preferable);
    • Experience with NGS data analysis;
    • Proficiency with Unix/Linux operating system;
    • Good English level;
    • Attention to details;
    • Ability to multitask, work and learn independently, and be self-motivated;
    • Ability to work in team and desire to collaborate with other bioinformaticians in the group is essential;
    • A strong work ethic and commitment to timely delivery of results.

    ESSENTIAL REQUIREMENTS

    • BSc. or MSc. in Bioinformatics-related subject (biology, bioinformatics, mathematics, statistics, physics, etc.);
    • Programming skills (Python, R,  preferable);
    • Experience with NGS data analysis;
    • Proficiency with Unix/Linux operating system;
    • Good English level;
    • Attention to details;
    • Ability to multitask, work and learn independently, and be self-motivated;
    • Ability to work in team and desire to collaborate with other bioinformaticians in the group is essential;
    • A strong work ethic and commitment to timely delivery of results.

    PREFERRED QUALIFICATIONS

    • Ph.D. in Bioinformatics or equal experience;
    • Experience with genomics data analysis;
    • Prior experience working with large-scale datasets using high performance computing environments is desirable.
    • Experience with Cancer genomics and bioinformatics related resources (TCGA, ICGC, COSMIC, etc.)
    • experience with database construction and maintenance

     

     

    For further info or to arrange an informal interview, please write to: luca.mazzarella@ieo.it

     

     

     

  • Bioinformatic Postdoc Position

    The candidate will join a team coordinated by dr Luca Mazzarella and will operate at the interface between clinical and basic research to explore molecular mechanisms of cancer pathogenesis and therapeutic resistance, with a highly multidisciplinary approach

    Specific interests in the lab are

    -the interplay between chromatin and metabolism in cancer biology and immuno-therapy (Mazzarella et al Blood 2015 126:459, Rossi et al Science Adv 2016)

    -the development of novel computational tools for the usage and interpretation of genomic data (see Melloni et al, Genome Med 2014, Breast Cancer Res Treat 2017, JCO Prec Oncol 2018)

    -the exploration of resistance mechanisms to novel therapeutics in breast and ovarian cancers.

    -the elucidation of molecular mechanisms underlying myeloproliferative neoplasms (MPN). On this topic, the lab was recently awarded a grant to elucidate genetic alterations associated with "triple-negative" and familial MPN, using novel long-read sequencing technologies (linked reads by 10x genomics, Nanopore sequencing), in collaboration with the University of Pavia, host to one of the largest existing collections of MPN samples.

     

    The candidate shall operate within the IEO campus and in contact with the Clinical Genomics unit at IEO, within a large and expanding bioinformatics community. Available state-of-the-art facilities include Illumina Novaseq and HiSeq, ION Torrent S5, 10x Chromium, Oxford Nanopore sequencers.

    The applicant must have excellent analytical skills, a strong statistical background, ability to work independently and as part of a team, very good oral/written communication and interpersonal skills to efficiently interact with the experimental collaborators and write and/or contribute to production of research reports and publications for peer reviewed journals.

     

    Required skills are:

    • A PhD-level background in a related discipline. Candidates with non-biological background, including Computer Science, Engineering, Mathematics, Statistics or Physics, are strongly encouraged to apply
    • Experience in software and algorithm development
    • Proficiency in the R environment
    • Strong programming skills in at least one of the following languages: Python, Perl, Java, C++
    • Proficiency in Unix/Linux operating systems
    • Familiarity with High-Performance Computing
    • Experience with analysis of large genomics datasets. Specific experience on Whole Exome/Genome Sequencing is desirable but by no means required

     

    For further info or to arrange an informal interview, please write to

    luca.mazzarella@ieo.it

     

  • POSTDOCTORAL POSITION IN COMPUTATIONAL CANCER BIOLOGY

    We are looking for a highly motivated postdoctoral fellow to join the new computational cancer biology lab of Martin Schaefer at the European Institute of Oncology (IEO) in Milan. The position is funded by a 5 year AIRC grant to Martin Schaefer.

     

    We aim to develop an understanding of cancer as a complex and evolving system. The aim of this position is to study the interaction of tumor cells with the local microbiome and other components of the microenvironment. The project will involve developing computational methods for the analysis of sequencing data and applying them to multi-omics data from clinical and laboratory samples.

     

    Candidates should hold a PhD (in a relevant area), have expertise in statistics, programming and the analysis of omics data and have a basic understanding of human molecular biology. Knowledge of data science techniques such as machine learning and being familiar with concepts of tumor evolution are a plus.

     

    More information on the lab of Martin Schaefer can be found at www.schaeferlab.org.

     

    For more information on the position or for sending an application (which should include a CV, cover letter, a list of publications and contact details of 2 - 3 referees) please contact: martin.schaefer@ieo.it. The position is available immediately but the starting date can be negotiated. The deadline for applications is March 1 2019.

  • Postdoc in molecular oncology at the Department of Experimental Oncology, IEO, Milan

    The candidate will be jointly supervised by Prof Piergiuseppe Pelicci and Dr Luca Mazzarella to explore molecular mechanisms of acute myeloid leukemias (AML).

    The lab is extensively exploring the interaction between systemic metabolism (modulated by obesity, caloric restriction, intermittent fasting), chromatin dynamics and the regulation of protein quality control (ER stress, UPR) in mouse models of AML, a research project stemming from clinical observations (Breccia, Mazzarella et al Blood 2012).

    In particular, we have intensively investigated the biology of the FLT3 kinase, the most commonly mutated gene in AML. We have found that the most frequent genetic alterations involving FLT3 perturb the phyisological folding, maturation and intracellular localization of the protein. This causes global alterations in cellular metabolism which may be favoured by specific dietary components, and creates vulnerabilities that could be targeted pharmacologically.

    The candidate will be asked to pursue a research program aimed at exploring the biology of mutant FLT3 using a combination of imaging, transcriptomics, proteomics and metabolomics techniques.

     

    The candidate will join a growing and stimulating research environment at the interface between the clinics and the lab, in a research institute of excellence with state-of-the-art equipment for

    • DNA/RNA sequencing (Illumina Novaseq and Hiseq, Chromium 10x, Nanopore MinIon and GridIon sequencers). In particular the institute has accumulated wide experience on single-cell sequencing (largest center in Italy by volume)
    • imaging, with multiple confocal microscopies (Leica DM6-B, SP8-CSU, SP8-FSU, TIRF) and equipment for live cell-imaging
    • flow cytometry with 3 analyzers (2 FacsCelesta, 1 MACSQuant) and 3 cell sorters (FACSMelody, FacsAria Fusion and FacsJazz)
    • proteomics/metabolomics unit equipped with a Q Exactive HF hybrid quadrupole-Orbitrap mass spectrometer coupled with a EASY-nLC 1200 Ultra-HPLC chromatography

    Requirements:

    • PhD-level background in biology, medicine or biotechnology
    • Documented experience with in vivo mouse models for molecular oncology (specific experience in hematology is highly desirable)
    • Familiarity with flow cytometry and fluorescence microscopy
    • Documented experience in at least one of the following: RNAseq, signal transduction analysis, metabolomics, proteomics, endoplasmic reticulum biology
    • Ability to work independently and as part of a team
    • Very good oral/written communication and interpersonal skills
    • Ability to independently write research reports and publications for peer reviewed journals

     

    For further info or to arrange an informal interview, please write to

    luca.mazzarella@ieo.it

     

  • Postdoctoral fellowship “Nuclear proteomics”

    One postdoctoral fellowship is immediately available in the Bonaldi Group “Nuclear proteomics”, at the Department of Experimental Oncology at the European Institute of Oncology in Milan, to develop a project focused on the molecular characterisation of the protein-methyl-proteome by MS approaches and the assessment of the functional role of protein-methylation in various cellular processes.  

    We are looking for an enthusiastic, motivated person, with a proven track record in biochemistry, or molecular and cellular biology. Demonstrated ability in interpersonal communication and collaboration, as well as strong initiative and ability to work independently, to drive the project forward are essential.  

     

    The post-doctoral fellow will work in a AIRC-funded project, we cutting-edge proteomics approaches will be designed and implemented for the in- depth analysis of the extent and dynamics of the human methyl-proteome, in response to various external cues and to its pharmacological modulation by epigenetics drugs.

     

    Requirements: PhD in one of the following discipline: Biology, Molecular Biology, Biochemistry, Molecular Medicine. Strong motivation and research commitment; excellent analytical and organization skill; a background in MS-based proteomics is highly appreciated, even though not essential.

    Competitive salaries will depend on the candidate’s track record and experience.

    The operating language of the lab is English.

    The position is up to three years.

     

    The European Institute of Oncology is one of Europe’s most influential cancer research institutes. The IEO operates as a Comprehensive Cancer Center, linking fundamental and applied research to clinical activities, patient care and clinical trials. The department of Experimental Oncology (DEO) is currently composed of ~250 scientists working in 15 independent research groups and units. DEO is located within a scientific campus together with two other partner institutions: the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT). The IEO is one of the 13 members of the EU-LIFE alliance to promote excellence in life sciences in Europe.

     

    IEO is an equal opportunity employer committed to excellence through diversity.

     

    Applicants should contact Dr. Tiziana Bonaldi, sending an e-mail with a brief description of interests and a CV at: tiziana.bonaldi@ieo.it.

    Application deadline: June 1st 2019

     

    https://www.ieo.it/en/RESEARCH/People/Researchers/Bonaldi-Tiziana/

  • BIOINFORMATIC POSITION IN EPIGENETIC MECHANISMS IN STEM CELL DIFFERENTIATION AND ONCOGENESIS UNIT

    BIOINFORMATIC POSITION IN EPIGENETIC MECHANISMS IN STEM CELL DIFFERENTIATION AND ONCOGENESIS UNIT

     

    A bioinformaticians position in the Research Group of Prof. Diego Pasini at the European Institute of Oncology (IEO, Milan) is immediately available.

     

    This call is open to applicants at any level.

     

    We are seeking highly motivated scientists with a proven background in bioinformatics/computational biology/informatics to uncover the transcriptional and epigenetic networks induced by defined oncogenic events and decrypt the molecular insights of chromatin remodelling activities in tissue homeostasis and cancer development. The project will involve the analysis of next generation sequencing (NGS) data produced with cutting edge technologies including ChIP-seq, ATAC-seq, RNA-seq and Single Cell transcriptomic from stem cell as well as in vivo, ex vivo and patients derived organoids cultures. The candidate will work in close collaboration with bioinformaticians and researchers at the Department of Experimental Oncology, a dynamic and stimulating scientific environment, and will have access to all needed computational infrastructures.

     

    Desired qualifications

    The candidate must have knowledge of numerical analysis environments (in particular R) and programming skills in at least one language. Candidates with good knowledge of biological systems or documented experience in high throughput data analysis (i.e. NGS) are particularly encouraged to apply. The candidate should have excellent communication and collaboration skills and good knowledge of English. He/she is also welcome to propose and conduct new lines of research in computational biology that align with the general interests of the lab.

     

    A competitive salary will be offered depending on experience.

     

    Application details

    Applicants should summit a brief motivation letter, CV, and contact details for two referees to: Dr. Karin Ferrari (karinjohanna.ferrari@ieo.it).

     

    For more info

    Website: https://www.ieo.it/en/RESEARCH/People/Researchers/Pasini-Diego/

    Research Gate: https://www.researchgate.net/profile/Diego_Pasini

    Full publication list (PubMed): https://www.ncbi.nlm.nih.gov/pubmed/?term=Diego+Pasini

  • POST-DOCTORAL POSITION IN EPIGENETIC MECHANISMS IN STEM CELL DIFFERENTIATION AND ONCOGENESIS UNIT

    POST-DOCTORAL POSITION IN EPIGENETIC MECHANISMS IN STEM CELL DIFFERENTIATION AND ONCOGENESIS UNIT

     

    A post-doctoral position in the Research Group of Prof. Diego Pasini at the European Institute of Oncology (IEO, Milan). The position will be filled as soon as we have identified the ideal candidate.

     

    We are seeking ambitious and hard-working candidates for a project focused at characterizing chromatin remodelling activities in stem cells and adult tissue homeostasis under physiological and oncogenic conditions. The research activity will take place at the Department of Experimental Oncology, a highly competitive, international and scientifically stimulating environment, and will involve the use of genetic, biochemical, transcriptomic and epigenomic approaches applied to stem cell, in vivo genetic mouse models as well as 3D organoids models derived from compound mice or patient samples.

     

    Desired qualifications

    Candidates with a Ph.D. in life sciences and skills in molecular and cellular biology are invited to apply. Proven experience with mouse handling, histology, in vitro 3D cultures, chromatin biology and NGS-related approaches will be an added advantage. Proficient English, independent working capacity, excellent organizational and collaborative skills are key requirements. Candidates are expected to be self-motivated research scientists driven by scientific curiosity and proactive in developing personal lines of research on the topic of the group.

     

    A competitive salary will be offered depending on experience.

     

    Application details

    Applicants should summit a brief motivation letter, CV, and contact details for two referees to: Dr. Karin Ferrari (karinjohanna.ferrari@ieo.it).

     

    For more info

    Website: https://www.ieo.it/en/RESEARCH/People/Researchers/Pasini-Diego/

    Research Gate: https://www.researchgate.net/profile/Diego_Pasini

    Full publication list (PubMed): https://www.ncbi.nlm.nih.gov/pubmed/?term=Diego+Pasini

  • Fellowship in the group of 'Nuclear Proteomics'

    One short-term fellowship is immediately available in the Group of Nuclear proteomics run by Tiziana Bonaldi at the Department of Experimental Oncology at the European Institute of Oncology in Milan, Italy, to contribute to the development of the project “MS proteomics-based analysis of epigenetic enzymes and their substrates in cancer model systems, with a special focus on methyl-transferases”. We are looking for a young, enthusiastic person, with good organizational and relational skills, and good knowledge of English.

     

    Requirements: Master’s degree in one of the following disciplines: Biology, Biotechnology, Pharmaceutical Sciences, Chemistry. Strong motivation and research commitment; excellent analytical and wet-bench skill; ability to work in team.

    Salary will depend on the candidate’s track record and experience.

    The operating language of the lab is English.

     

    The European Institute of Oncology is one of Europe’s most influential cancer research institutes. The IEO operates as a Comprehensive Cancer Center, linking fundamental and applied research to clinical activities, patient care and clinical trials. The department of Experimental Oncology (DEO) is currently composed of ~250 scientists working in 15 independent research groups and units. DEO is located within a scientific campus together with two other partner institutions: the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT). The IEO is one of the 13 members of the EU-LIFE alliance to promote excellence in life sciences in Europe.

    IEO is an equal opportunity employer, committed to excellence through diversity.

     

    Applicants should contact Dr. Tiziana Bonaldi, sending an e-mail with a brief description of interests, a CV and at least one reference letter at: tiziana.bonaldi@ieo.it.

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