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Immunobiology of Dendritic Cells and Immunotherapy

Director

Maria Rescigno

Activities

Dendritic cells (DC) comprise a family of professional antigen presenting cells unique in their capacity to modulate T cell responses. DC play a primary role in pathogen protection, in central and peripheral tolerance and in anticancer immune responses.

  • Research projects

    In our unit we have two major lines of research:

    We are using bacteria to successfully exploit antigen presentation and to develop new ways to target tumor antigens into dendritic cells. We are also using bacteria to target tumor cells via the generation of intelligent missiles that will recognize only tumor cells and will deliver payloads of enzymes important for the catabolization of prodrugs into active anticancer agents. Finally, we are trying to understand the mechanism of resistance to tumor targeted therapy that involves the activation of the immune system.

    In the second line of research, as a deregulation in bacterial handling has been associated with the development of inflammatory bowel disease, we want to understand the basis of bacterial handling in the gut. We found that even though dendritic cells encounter bacteria in the gut they are inhibited in their inflammatory potential. We are studying how deregulation in bacteria handling can affect the homeostasis of the gut and eventually lead to cancer or inflammatory bowel disorders.

  • Educational Activities

    Since 2001 faculty member of SEMM.

     

    Coordinator of SIPOD: Structured international Post-doctoral programme

    Organizer of the Immunology course for the PhD programme

    Organizer of the Clinical trial course for the SIPOD

     

    2007-2012 Visiting Professor University of Oslo

     

UN PICCOLO GESTO E' PER NOI UN GRANDE AIUTO

PARTNERSHIP

Università degli Studi di Milano Ecancer Medical Science IFOM-IEO Campus

ACCREDITAMENTI

Ministero della Salute Joint Commission International Breastcertification bollinirosa

© 2013 Istituto Europeo di Oncologia - via Ripamonti 435 Milano - P.I. 08691440153

IRCCS - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

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